Antioxidant, Antiinflammatory, and Antifibrotic Properties of Quercetin in the Liver

L. F. Vázquez-Flores; S. Casas-Grajales; E. Hernández-Aquino; E. E. Vargas-Pozada; P. Muriel

doi:10.1016/B978-0-12-804274-8.00047-3

Antioxidant, Antiinflammatory, and Antifibrotic Properties of Quercetin in the Liver

L. F. Vázquez-Flores^*
, S. Casas-Grajales
, E. Hernández-Aquino
, E. E. Vargas-Pozada
, P. Muriel

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter

29 Scopus citations

Abstract

Quercetin (Q) is a ubiquitous flavonoid founded in several natural sources, mainly in skin apples and red onions. Q possesses potent antioxidant properties, as well as metal-chelating property, sufficient reasons for years worthy of investigation. Experimental evidence shows that Q possesses anti-inflammatory and antifibrotic capacities, which together are beneficial for the treatment of liver diseases. This chapter will explain how Q exerts its effect on liver diseases and the relevant aspects of its chemistry and pharmacokinetic and pharmaceutical technologies. Nevertheless, toxicological effects of Q were also reported; for this reason more studies are necessary to determine the best conditions for the use of Q for the treatment of liver diseases.

Original language	English
Title of host publication	Liver Pathophysiology
Subtitle of host publication	Therapies and Antioxidants
Publisher	Elsevier
Pages	653-674
Number of pages	22
ISBN (Electronic)	9780128043219
ISBN (Print)	9780128042748
DOIs	https://doi.org/10.1016/B978-0-12-804274-8.00047-3
State	Published - 23 Mar 2017
Externally published	Yes

Keywords

Anti-inflammatory
Antifibrogenic
Antioxidant
Flavonoid
Hepatocellular carcinoma
Liver diseases
Pharmaceutical technology
Pharmacokinetic
Quercetin
Toxicological effects

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10.1016/B978-0-12-804274-8.00047-3

Cite this

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abstract = "Quercetin (Q) is a ubiquitous flavonoid founded in several natural sources, mainly in skin apples and red onions. Q possesses potent antioxidant properties, as well as metal-chelating property, sufficient reasons for years worthy of investigation. Experimental evidence shows that Q possesses anti-inflammatory and antifibrotic capacities, which together are beneficial for the treatment of liver diseases. This chapter will explain how Q exerts its effect on liver diseases and the relevant aspects of its chemistry and pharmacokinetic and pharmaceutical technologies. Nevertheless, toxicological effects of Q were also reported; for this reason more studies are necessary to determine the best conditions for the use of Q for the treatment of liver diseases.",

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AU - Vázquez-Flores, L. F.

AU - Casas-Grajales, S.

AU - Hernández-Aquino, E.

AU - Vargas-Pozada, E. E.

AU - Muriel, P.

PY - 2017/3/23

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AB - Quercetin (Q) is a ubiquitous flavonoid founded in several natural sources, mainly in skin apples and red onions. Q possesses potent antioxidant properties, as well as metal-chelating property, sufficient reasons for years worthy of investigation. Experimental evidence shows that Q possesses anti-inflammatory and antifibrotic capacities, which together are beneficial for the treatment of liver diseases. This chapter will explain how Q exerts its effect on liver diseases and the relevant aspects of its chemistry and pharmacokinetic and pharmaceutical technologies. Nevertheless, toxicological effects of Q were also reported; for this reason more studies are necessary to determine the best conditions for the use of Q for the treatment of liver diseases.

KW - Anti-inflammatory

KW - Antifibrogenic

KW - Antioxidant

KW - Flavonoid

KW - Hepatocellular carcinoma

KW - Liver diseases

KW - Pharmaceutical technology

KW - Pharmacokinetic

KW - Quercetin

KW - Toxicological effects

UR - https://www.scopus.com/pages/publications/85032976991

U2 - 10.1016/B978-0-12-804274-8.00047-3

DO - 10.1016/B978-0-12-804274-8.00047-3

M3 - Capítulo

AN - SCOPUS:85032976991

SN - 9780128042748

SP - 653

EP - 674

BT - Liver Pathophysiology

PB - Elsevier

ER -

Antioxidant, Antiinflammatory, and Antifibrotic Properties of Quercetin in the Liver

Abstract

Keywords

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