Cannabinoids, sleep, and the MCH system

Eric Murillo-Rodríguez; Daniela Morales-Lara; José Carlos Pastrana-Trejo; Lorena Macías-Triana; Karen Romero-Cordero; Miriel de-la-Cruz; Clelia De-la-Peña

doi:10.1007/978-3-319-75765-0_6

Cannabinoids, sleep, and the MCH system

Eric Murillo-Rodríguez^*, Daniela Morales-Lara, José Carlos Pastrana-Trejo, Lorena Macías-Triana, Karen Romero-Cordero, Miriel de-la-Cruz, Clelia De-la-Peña

^*Corresponding author for this work

Anahuac Mayab University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Marijuana is a colloquial name given to Cannabis sativa, which has been used for diverse purposes, including as a therapeutical element for multiple health issues. The neurobiological effects of C. sativa involve a complex biological machinery including receptors, named CB₁ and CB₂ cannabinoid receptors. These receptors recognize endogenous cannabinoid-like compounds, such as anandamide and 2-arachinonolglycerol which seems to display sleep-inducing properties. Along decades, the study of the putative role of exogenous and endogenous cannabinoids in sleep modulation has brought critical data. Since endocannabinoids have been described in sleep-related brain areas, intriguing issues regarding whether hypothalamic substrates, such as MHC, may be interacting with the endocannabinoids have been raised.

Original language	English
Title of host publication	Melanin-Concentrating Hormone and Sleep
Subtitle of host publication	Molecular, Functional and Clinical Aspects
Publisher	Taylor and Francis
Pages	121-130
Number of pages	10
ISBN (Electronic)	9783319757650
ISBN (Print)	9783319757643
DOIs	https://doi.org/10.1007/978-3-319-75765-0_6
State	Published - 17 Apr 2018

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abstract = "Marijuana is a colloquial name given to Cannabis sativa, which has been used for diverse purposes, including as a therapeutical element for multiple health issues. The neurobiological effects of C. sativa involve a complex biological machinery including receptors, named CB1 and CB2 cannabinoid receptors. These receptors recognize endogenous cannabinoid-like compounds, such as anandamide and 2-arachinonolglycerol which seems to display sleep-inducing properties. Along decades, the study of the putative role of exogenous and endogenous cannabinoids in sleep modulation has brought critical data. Since endocannabinoids have been described in sleep-related brain areas, intriguing issues regarding whether hypothalamic substrates, such as MHC, may be interacting with the endocannabinoids have been raised.",

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AU - Pastrana-Trejo, José Carlos

AU - Macías-Triana, Lorena

AU - Romero-Cordero, Karen

AU - de-la-Cruz, Miriel

AU - De-la-Peña, Clelia

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Cannabinoids, sleep, and the MCH system

Abstract

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