TY - JOUR
T1 - Cellular immune response and TH1/TH2 cytokines in human neurocysticercosis
T2 - Lack of immune suppression
AU - Medina-Escutia, E.
AU - Morales-López, Z.
AU - Proaño, J. V.
AU - Vázquez, J.
AU - Bermúdez, V.
AU - Ortiz-Navarrete, V.
AU - Madrid-Marina, V.
AU - Laclette, J. P.
AU - Correa, D.
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Some reports have suggested that human neurocysticercosis (NCC) induces immunosuppression. To test this hypothesis, we performed a study on active cases of NCC who had not received cestocidal or immunosuppressive treatments. We examined blood counts and specific T cell markers (CD3, CD4, and CD8) by flow cytometry and found no differences between patients with NCC and healthy individuals. Both groups responded to concanavalin A (Con A), and patients with NCC responded more to a parasite crude antigen than uninfected individuals. Peripheral blood mononuclear cells were examined for interleukin (IL)-2, interferon-γ, IL-10, and IL-4 mRNA. Regardless of infection status, more than 60% of individuals synthesized IL-2 mRNA and, less frequently, the other cytokines. These data suggest that immunosuppression does not occur in NCC patients.
AB - Some reports have suggested that human neurocysticercosis (NCC) induces immunosuppression. To test this hypothesis, we performed a study on active cases of NCC who had not received cestocidal or immunosuppressive treatments. We examined blood counts and specific T cell markers (CD3, CD4, and CD8) by flow cytometry and found no differences between patients with NCC and healthy individuals. Both groups responded to concanavalin A (Con A), and patients with NCC responded more to a parasite crude antigen than uninfected individuals. Peripheral blood mononuclear cells were examined for interleukin (IL)-2, interferon-γ, IL-10, and IL-4 mRNA. Regardless of infection status, more than 60% of individuals synthesized IL-2 mRNA and, less frequently, the other cytokines. These data suggest that immunosuppression does not occur in NCC patients.
UR - https://www.scopus.com/pages/publications/0034973354
U2 - 10.1645/0022-3395(2001)087[0587:ciratt]2.0.co;2
DO - 10.1645/0022-3395(2001)087[0587:ciratt]2.0.co;2
M3 - Artículo
C2 - 11426722
AN - SCOPUS:0034973354
SN - 0022-3395
VL - 87
SP - 587
EP - 590
JO - Journal of Parasitology
JF - Journal of Parasitology
IS - 3
ER -