TY - JOUR
T1 - Co-Enzyme Q10 to treat neurological disorders
T2 - Basic mechanisms, clinical outcomes, and future research direction
AU - Salama, Mohamed
AU - Yuan, Ti Fei
AU - Machado, Sergio
AU - Murillo-Rodríguez, Eric
AU - Vega, José A.
AU - Menéndez-González, Manuel
AU - Nardi, Antonio E.
AU - Arias-Carrión, Oscar
PY - 2013/8/28
Y1 - 2013/8/28
N2 - Coenzyme Q10 (CoQ10) is critical for the cell power supply in mitochondria. CoQ10 shuttles electrons from complexes I and II to complex III, and can be anti-oxdiative. Neurons require high energy for synaptic transmission and therefore the mitochondria dysfunction often leads to severe neuronal degeneration, as observed in many neurological disorders. CoQ10 supplementation has been widely used to treat aging, stroke, neuromuscular diseases, Alzheimer's disease, Parkinson's disease, progressive supranuclear palsy, autosomal recessive cerebellar ataxias, Huntington's disease and amyotrophic lateral sclerosis. Here we discuss a large number of preclinical and clinical trials for CoQ10 to elucidate the mechanisms underlying CoQ10 therapy. The rational applications as a therapeutic agent in neurological disorders are discussed.
AB - Coenzyme Q10 (CoQ10) is critical for the cell power supply in mitochondria. CoQ10 shuttles electrons from complexes I and II to complex III, and can be anti-oxdiative. Neurons require high energy for synaptic transmission and therefore the mitochondria dysfunction often leads to severe neuronal degeneration, as observed in many neurological disorders. CoQ10 supplementation has been widely used to treat aging, stroke, neuromuscular diseases, Alzheimer's disease, Parkinson's disease, progressive supranuclear palsy, autosomal recessive cerebellar ataxias, Huntington's disease and amyotrophic lateral sclerosis. Here we discuss a large number of preclinical and clinical trials for CoQ10 to elucidate the mechanisms underlying CoQ10 therapy. The rational applications as a therapeutic agent in neurological disorders are discussed.
KW - ATP
KW - Coenzyme Q10
KW - Mitochondrial respiratory chain
KW - Neurological disorders
KW - Rational therapeutic approaches
UR - http://www.scopus.com/inward/record.url?scp=84882763118&partnerID=8YFLogxK
U2 - 10.2174/18715273113129990071
DO - 10.2174/18715273113129990071
M3 - Artículo
AN - SCOPUS:84882763118
SN - 1871-5273
VL - 12
SP - 641
EP - 644
JO - CNS and Neurological Disorders - Drug Targets
JF - CNS and Neurological Disorders - Drug Targets
IS - 5
ER -