Development and characterization of nanocapsules comprising dodecyltrimethylammonium chloride and κ-carrageenan

A. Rosas-Durazo; J. Lizardi; I. Higuera-Ciapara; W. Argüelles-Monal; F. M. Goycoolea

doi:10.1016/j.colsurfb.2011.03.020

Development and characterization of nanocapsules comprising dodecyltrimethylammonium chloride and κ-carrageenan

A. Rosas-Durazo, J. Lizardi, I. Higuera-Ciapara, W. Argüelles-Monal, F. M. Goycoolea

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The aim of this work was to develop and characterize a new type of nanocapsules. To this end, a nanoemulsion bearing an oily core (Miglyol 812) was obtained by spontaneous emulsification and stabilized by dodecyl-trimethylammonium chloride (DTAC), a commercial cationic surfactant; this nanoemulsion was coated with proportionally very small amounts of κ-carrageenan (at molar charge ratios of Z≤ 0.0045) that interact predominantly by an electrostatic mechanism with the positively charged sites at the polar heads of DTAC at the nanoemulsion's surface to harness nanocapsules of average size ∼250-330. nm and zeta potential (ζ) ranging from ∼+80 to +7. mV. The potential application of the new type of developed nanosystems as drug delivery vehicles has yet to be investigated and fully realized.

Original language	English
Pages (from-to)	242-246
Number of pages	5
Journal	Colloids and Surfaces B: Biointerfaces
Volume	86
Issue number	1
DOIs	https://doi.org/10.1016/j.colsurfb.2011.03.020
State	Published - 1 Aug 2011
Externally published	Yes

Keywords

Carrageenan
Dodecyltrimethylammonium chloride
Nanocapsules

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10.1016/j.colsurfb.2011.03.020

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title = "Development and characterization of nanocapsules comprising dodecyltrimethylammonium chloride and κ-carrageenan",

abstract = "The aim of this work was to develop and characterize a new type of nanocapsules. To this end, a nanoemulsion bearing an oily core (Miglyol 812) was obtained by spontaneous emulsification and stabilized by dodecyl-trimethylammonium chloride (DTAC), a commercial cationic surfactant; this nanoemulsion was coated with proportionally very small amounts of κ-carrageenan (at molar charge ratios of Z≤ 0.0045) that interact predominantly by an electrostatic mechanism with the positively charged sites at the polar heads of DTAC at the nanoemulsion's surface to harness nanocapsules of average size ∼250-330. nm and zeta potential (ζ) ranging from ∼+80 to +7. mV. The potential application of the new type of developed nanosystems as drug delivery vehicles has yet to be investigated and fully realized.",

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AU - Rosas-Durazo, A.

AU - Lizardi, J.

AU - Higuera-Ciapara, I.

AU - Argüelles-Monal, W.

AU - Goycoolea, F. M.

PY - 2011/8/1

Y1 - 2011/8/1

N2 - The aim of this work was to develop and characterize a new type of nanocapsules. To this end, a nanoemulsion bearing an oily core (Miglyol 812) was obtained by spontaneous emulsification and stabilized by dodecyl-trimethylammonium chloride (DTAC), a commercial cationic surfactant; this nanoemulsion was coated with proportionally very small amounts of κ-carrageenan (at molar charge ratios of Z≤ 0.0045) that interact predominantly by an electrostatic mechanism with the positively charged sites at the polar heads of DTAC at the nanoemulsion's surface to harness nanocapsules of average size ∼250-330. nm and zeta potential (ζ) ranging from ∼+80 to +7. mV. The potential application of the new type of developed nanosystems as drug delivery vehicles has yet to be investigated and fully realized.

AB - The aim of this work was to develop and characterize a new type of nanocapsules. To this end, a nanoemulsion bearing an oily core (Miglyol 812) was obtained by spontaneous emulsification and stabilized by dodecyl-trimethylammonium chloride (DTAC), a commercial cationic surfactant; this nanoemulsion was coated with proportionally very small amounts of κ-carrageenan (at molar charge ratios of Z≤ 0.0045) that interact predominantly by an electrostatic mechanism with the positively charged sites at the polar heads of DTAC at the nanoemulsion's surface to harness nanocapsules of average size ∼250-330. nm and zeta potential (ζ) ranging from ∼+80 to +7. mV. The potential application of the new type of developed nanosystems as drug delivery vehicles has yet to be investigated and fully realized.

KW - Carrageenan

KW - Dodecyltrimethylammonium chloride

KW - Nanocapsules

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DO - 10.1016/j.colsurfb.2011.03.020

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SN - 0927-7765

VL - 86

SP - 242

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JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

IS - 1

ER -

Development and characterization of nanocapsules comprising dodecyltrimethylammonium chloride and κ-carrageenan

Abstract

Keywords

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