Development of post-traumatic cysts in the spinal cord of rats subjected to severe spinal cord contusion

Gabriel Guizar-Sahagun; Israel Grijalva; Ignacio Madrazo; Rebecca Franco-Bourland; Hermelinda Salgado; Antonio Ibarra; Elena Oliva; Armando Zepeda

doi:10.1016/0090-3019(94)90131-7

Development of post-traumatic cysts in the spinal cord of rats subjected to severe spinal cord contusion

Gabriel Guizar-Sahagun, Israel Grijalva, Ignacio Madrazo, Rebecca Franco-Bourland, Hermelinda Salgado, Antonio Ibarra, Elena Oliva, Armando Zepeda

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

To study the development of post-traumatic spinal cord (SC) cysts, and their fine anatomic characteristics, rats were subjected to severe SC contusion. Specimens were analyzed from day 1 to 1 year post-injury. Using conventional light, and transmission and scanning electron microscopy, three stages were typified, namely: necrosis, repair, and stability. The final cell composition and thickness of the cyst walls were not uniform. Astrocytes, fibroblasts, ependymal cells, and collagen fibers were the main constituents. Chronic inflammatory cells were also observed. The neuropathologic characterization of post-traumatic SC cysts could be useful in planning strategies for SC reconstruction at different times post-injury.

Original language	English
Pages (from-to)	241-249
Number of pages	9
Journal	Surgical Neurology
Volume	41
Issue number	3
DOIs	https://doi.org/10.1016/0090-3019(94)90131-7
State	Published - 1 Jan 1994
Externally published	Yes

Keywords

Experimental spinal cord injury
Paraplegia
Post-traumatic cysts
Spinal cord contusion

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10.1016/0090-3019(94)90131-7

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title = "Development of post-traumatic cysts in the spinal cord of rats subjected to severe spinal cord contusion",

abstract = "To study the development of post-traumatic spinal cord (SC) cysts, and their fine anatomic characteristics, rats were subjected to severe SC contusion. Specimens were analyzed from day 1 to 1 year post-injury. Using conventional light, and transmission and scanning electron microscopy, three stages were typified, namely: necrosis, repair, and stability. The final cell composition and thickness of the cyst walls were not uniform. Astrocytes, fibroblasts, ependymal cells, and collagen fibers were the main constituents. Chronic inflammatory cells were also observed. The neuropathologic characterization of post-traumatic SC cysts could be useful in planning strategies for SC reconstruction at different times post-injury.",

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AU - Guizar-Sahagun, Gabriel

AU - Grijalva, Israel

AU - Madrazo, Ignacio

AU - Franco-Bourland, Rebecca

AU - Salgado, Hermelinda

AU - Ibarra, Antonio

AU - Oliva, Elena

AU - Zepeda, Armando

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N2 - To study the development of post-traumatic spinal cord (SC) cysts, and their fine anatomic characteristics, rats were subjected to severe SC contusion. Specimens were analyzed from day 1 to 1 year post-injury. Using conventional light, and transmission and scanning electron microscopy, three stages were typified, namely: necrosis, repair, and stability. The final cell composition and thickness of the cyst walls were not uniform. Astrocytes, fibroblasts, ependymal cells, and collagen fibers were the main constituents. Chronic inflammatory cells were also observed. The neuropathologic characterization of post-traumatic SC cysts could be useful in planning strategies for SC reconstruction at different times post-injury.

AB - To study the development of post-traumatic spinal cord (SC) cysts, and their fine anatomic characteristics, rats were subjected to severe SC contusion. Specimens were analyzed from day 1 to 1 year post-injury. Using conventional light, and transmission and scanning electron microscopy, three stages were typified, namely: necrosis, repair, and stability. The final cell composition and thickness of the cyst walls were not uniform. Astrocytes, fibroblasts, ependymal cells, and collagen fibers were the main constituents. Chronic inflammatory cells were also observed. The neuropathologic characterization of post-traumatic SC cysts could be useful in planning strategies for SC reconstruction at different times post-injury.

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KW - Paraplegia

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Development of post-traumatic cysts in the spinal cord of rats subjected to severe spinal cord contusion

Abstract

Keywords

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