Early effects of modulating nuclear factor-κB activation on traumatic spinal cord injury in rats

Octavio Jiménez-Garza; Javier Camacho; Antonio Ibarra; Angelina Martínez; Gabriel Guízar-Sahagún

doi:10.1196/annals.1344.012

Early effects of modulating nuclear factor-κB activation on traumatic spinal cord injury in rats

Octavio Jiménez-Garza, Javier Camacho, Antonio Ibarra, Angelina Martínez, Gabriel Guízar-Sahagún

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Genes regulated by NF-κB play an important role on secondary damage and repair after spinal cord injury (SCI). To assess the early effects of the pharmacological inhibition and overactivation of NF-κB, pyrrolidine dithiocarbamate (PDTC) or lipopolysaccharide were given to rats before or after SC contusion. The amount of spared SC tissue was higher (P < 0.05) at 24 h postinjury in rats posttreated with PDTC; both PDTC-treated rats showed no significant trend to decrease polymorphonuclear infiltrate. p65 subunit was present in inflammatory cells, neurons, and astrocytes at the injury site. These data support further investigation on functional effects of NF-κB inhibition in acute SCI.

Original language	English
Pages (from-to)	148-150
Number of pages	3
Journal	Annals of the New York Academy of Sciences
Volume	1053
DOIs	https://doi.org/10.1196/annals.1344.012
State	Published - 1 Jan 2005
Externally published	Yes

Keywords

Inflammation
Lipopolysaccharide
Nuclear factor-κB (NF-κB)
Pyrrolidine dithiocarbamate
Spared tissue
Spinal cord injury (SCI)

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10.1196/annals.1344.012

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abstract = "Genes regulated by NF-κB play an important role on secondary damage and repair after spinal cord injury (SCI). To assess the early effects of the pharmacological inhibition and overactivation of NF-κB, pyrrolidine dithiocarbamate (PDTC) or lipopolysaccharide were given to rats before or after SC contusion. The amount of spared SC tissue was higher (P < 0.05) at 24 h postinjury in rats posttreated with PDTC; both PDTC-treated rats showed no significant trend to decrease polymorphonuclear infiltrate. p65 subunit was present in inflammatory cells, neurons, and astrocytes at the injury site. These data support further investigation on functional effects of NF-κB inhibition in acute SCI.",

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AU - Jiménez-Garza, Octavio

AU - Camacho, Javier

AU - Ibarra, Antonio

AU - Martínez, Angelina

AU - Guízar-Sahagún, Gabriel

PY - 2005/1/1

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AB - Genes regulated by NF-κB play an important role on secondary damage and repair after spinal cord injury (SCI). To assess the early effects of the pharmacological inhibition and overactivation of NF-κB, pyrrolidine dithiocarbamate (PDTC) or lipopolysaccharide were given to rats before or after SC contusion. The amount of spared SC tissue was higher (P < 0.05) at 24 h postinjury in rats posttreated with PDTC; both PDTC-treated rats showed no significant trend to decrease polymorphonuclear infiltrate. p65 subunit was present in inflammatory cells, neurons, and astrocytes at the injury site. These data support further investigation on functional effects of NF-κB inhibition in acute SCI.

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KW - Lipopolysaccharide

KW - Nuclear factor-κB (NF-κB)

KW - Pyrrolidine dithiocarbamate

KW - Spared tissue

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Early effects of modulating nuclear factor-κB activation on traumatic spinal cord injury in rats

Abstract

Keywords

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