H NMR Studies of molecular interaction of D-glucosamine and N-acetyl-D-glucosamine with curcumin and caffeic acid phenethyl ester in DMSO

Inocencio Higuera Ciapara; Evelyn Martínez-Benavidez; Ana Lilia Sánchez; Zaira  Domínguez; Magali Salas-Reyes; Gustavo Adolfo Castillo-Herrera; Inocencio Higuera-Ciapara; Ofelia Yadira Lugo-Melchor; Motomichi Inoue; Claudia Virúes

H NMR Studies of molecular interaction of D-glucosamine and N-acetyl-D-glucosamine with curcumin and caffeic acid phenethyl ester in DMSO

Inocencio Higuera Ciapara
, Evelyn Martínez-Benavidez
, Ana Lilia Sánchez
, Zaira Domínguez
, Magali Salas-Reyes
, Gustavo Adolfo Castillo-Herrera
, Inocencio Higuera-Ciapara
, Ofelia Yadira Lugo-Melchor
, Motomichi Inoue
, Claudia Virúes

Research output: Contribution to journal › Article › peer-review

Abstract

In this study, we focused on designing CS-based drug carriers by examining the intermolecular interactions between the polymer components, D-glucosamine (Gn) and N-acetyl-D-glucosamine (AGn), and the target substances CUR and CAPE through 1H NMR titration in dimethyl sulfoxide (DMSO‑d6). The observed
changes in chemical shifts indicated that Gn cation (GnH+) forms molecular complexes, whereas AGn does not exhibit any intermolecular interaction

Translated title of the contribution	Estudios de Resonancia Magnética sobre la interacción de la D-glucosamina y la N-acetyl-D-glucosamina con la curcumina y el ester deniletilo en DMSO
Original language	English
Article number	109704
Pages (from-to)	1-8
Number of pages	8
Journal	Carbohydrate Research
Volume	558
Issue number	109704
Early online date	13 Oct 2025
State	Published - 13 Oct 2025

Cite this

Higuera Ciapara, I., Martínez-Benavidez, E., Sánchez, A. L., Domínguez, Z., Salas-Reyes, M., Castillo-Herrera, G. A., Higuera-Ciapara, I., Lugo-Melchor, O. Y., Inoue, M., & Virúes, C. (2025). H NMR Studies of molecular interaction of D-glucosamine and N-acetyl-D-glucosamine with curcumin and caffeic acid phenethyl ester in DMSO. Carbohydrate Research, 558(109704), 1-8. Article 109704.

@article{8e8aba529593440f8602f3cff45fac91,

title = "H NMR Studies of molecular interaction of D-glucosamine and N-acetyl-D-glucosamine with curcumin and caffeic acid phenethyl ester in DMSO",

abstract = "In this study, we focused on designing CS-based drug carriers by examining the intermolecular interactions between the polymer components, D-glucosamine (Gn) and N-acetyl-D-glucosamine (AGn), and the target substances CUR and CAPE through 1H NMR titration in dimethyl sulfoxide (DMSO‑d6). The observed changes in chemical shifts indicated that Gn cation (GnH+) forms molecular complexes, whereas AGn does not exhibit any intermolecular interaction",

keywords = "Interacciones, Moleculares, D-glucosamina, curcumina",

author = "\{Higuera Ciapara\}, Inocencio and Evelyn Mart{\'i}nez-Benavidez and S{\'a}nchez, \{Ana Lilia\} and Zaira Dom{\'i}nguez and Magali Salas-Reyes and Castillo-Herrera, \{Gustavo Adolfo\} and Inocencio Higuera-Ciapara and Lugo-Melchor, \{Ofelia Yadira\} and Motomichi Inoue and Claudia Vir{\'u}es",

year = "2025",

month = oct,

day = "13",

language = "Ingl{\'e}s",

volume = "558",

pages = "1--8",

journal = "Carbohydrate Research",

issn = "0008-6215",

publisher = "Elsevier Ltd.",

number = "109704",

}

Higuera Ciapara, I, Martínez-Benavidez, E, Sánchez, AL, Domínguez, Z, Salas-Reyes, M, Castillo-Herrera, GA, Higuera-Ciapara, I, Lugo-Melchor, OY, Inoue, M & Virúes, C 2025, 'H NMR Studies of molecular interaction of D-glucosamine and N-acetyl-D-glucosamine with curcumin and caffeic acid phenethyl ester in DMSO', Carbohydrate Research, vol. 558, no. 109704, 109704, pp. 1-8.

TY - JOUR

T1 - H NMR Studies of molecular interaction of D-glucosamine and N-acetyl-D-glucosamine with curcumin and caffeic acid phenethyl ester in DMSO

AU - Higuera Ciapara, Inocencio

AU - Martínez-Benavidez, Evelyn

AU - Sánchez, Ana Lilia

AU - Domínguez, Zaira

AU - Salas-Reyes, Magali

AU - Castillo-Herrera, Gustavo Adolfo

AU - Higuera-Ciapara, Inocencio

AU - Lugo-Melchor, Ofelia Yadira

AU - Inoue, Motomichi

AU - Virúes, Claudia

PY - 2025/10/13

Y1 - 2025/10/13

N2 - In this study, we focused on designing CS-based drug carriers by examining the intermolecular interactions between the polymer components, D-glucosamine (Gn) and N-acetyl-D-glucosamine (AGn), and the target substances CUR and CAPE through 1H NMR titration in dimethyl sulfoxide (DMSO‑d6). The observed changes in chemical shifts indicated that Gn cation (GnH+) forms molecular complexes, whereas AGn does not exhibit any intermolecular interaction

AB - In this study, we focused on designing CS-based drug carriers by examining the intermolecular interactions between the polymer components, D-glucosamine (Gn) and N-acetyl-D-glucosamine (AGn), and the target substances CUR and CAPE through 1H NMR titration in dimethyl sulfoxide (DMSO‑d6). The observed changes in chemical shifts indicated that Gn cation (GnH+) forms molecular complexes, whereas AGn does not exhibit any intermolecular interaction

KW - Interacciones

KW - Moleculares

KW - D-glucosamina

KW - curcumina

M3 - Artículo

SN - 0008-6215

VL - 558

SP - 1

EP - 8

JO - Carbohydrate Research

JF - Carbohydrate Research

IS - 109704

M1 - 109704

ER -