TY - JOUR
T1 - Intrahypothalamic injection of cannabidiol increases the extracellular levels of adenosine in nucleus accumbens in rats
AU - Mijangos-Moreno, Stephanie
AU - Poot-Aké, Alwin
AU - Arankowsky-Sandoval, Gloria
AU - Murillo-Rodríguez, Eric
N1 - Publisher Copyright:
© 2014 Elsevier Ireland Ltd and the Japan Neuroscience Society.
PY - 2014/7/1
Y1 - 2014/7/1
N2 - Cannabidiol (CBD) is a constituent of Cannabis sativa that promotes wakefulness as well as enhances endogenous levels of wake-related neurotransmitters, including dopamine. However, at this date, the effects of CBD on the sleep-inducing molecules, such as adenosine (AD), are unknown. Here, we report that intrahypothalamic injection of CBD (10. μg/1. μL) increases the extracellular levels of AD collected from nucleus accumbens. Furthermore, the pharmacodynamic of this drug shows that effects on the contents of AD last 2. h post-injection. These preliminary findings suggest that CBD promotes the endogenous accumulation of AD.
AB - Cannabidiol (CBD) is a constituent of Cannabis sativa that promotes wakefulness as well as enhances endogenous levels of wake-related neurotransmitters, including dopamine. However, at this date, the effects of CBD on the sleep-inducing molecules, such as adenosine (AD), are unknown. Here, we report that intrahypothalamic injection of CBD (10. μg/1. μL) increases the extracellular levels of AD collected from nucleus accumbens. Furthermore, the pharmacodynamic of this drug shows that effects on the contents of AD last 2. h post-injection. These preliminary findings suggest that CBD promotes the endogenous accumulation of AD.
KW - Adenosine
KW - HPLC
KW - Hypothalamus
KW - Microdialysis
KW - Wakefulness
UR - http://www.scopus.com/inward/record.url?scp=84908555675&partnerID=8YFLogxK
U2 - 10.1016/j.neures.2014.04.006
DO - 10.1016/j.neures.2014.04.006
M3 - Artículo
C2 - 24800644
AN - SCOPUS:84908555675
SN - 0168-0102
VL - 84
SP - 60
EP - 63
JO - Neuroscience Research
JF - Neuroscience Research
ER -