Lipid peroxidation inhibition in spinal cord injury: Cyclosporin-A vs methylprednisolone

Aracell Diaz-Ruiz; Camilo Rios; Ivonne Duarte; Dolores Correa; Gabriel Guizar-Sahagun; Israel Grijalva; Ignacio Madrazo; Antonio Ibarra

doi:10.1097/00001756-200006050-00033

Lipid peroxidation inhibition in spinal cord injury: Cyclosporin-A vs methylprednisolone

Aracell Diaz-Ruiz, Camilo Rios, Ivonne Duarte, Dolores Correa, Gabriel Guizar-Sahagun, Israel Grijalva, Ignacio Madrazo, Antonio Ibarra

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

To compare the effectiveness of cyclosporin-A (CsA) with methylprednisolone (MP) or a combination of both upon inhibition of lipid peroxidation (LP) after spinal cord (SC) injury, rats were treated with either CsA, MP, CSA+MP or vehicle starting 1 h after SC contusion at T9 level. LP was assessed 24h after injury by the lipid fluorescent product formation method. The survival rate was also evaluated in other series of rats by the Kaplan-Meier curves. Lipid peroxidation was similarly inhibited in rats treated with CsA, MP, or CSA+MP (p > 0.05). Animals receiving MP (alone or combined with CsA) showed the poorest surviving rate. LP was inhibited by CsA to the same extent as by MP but without the lethal effect of the latter. (C) 2000 Lippincott Williams and Wilkins.

Original language	English
Pages (from-to)	1765-1767
Number of pages	3
Journal	NeuroReport
Volume	11
Issue number	8
DOIs	https://doi.org/10.1097/00001756-200006050-00033
State	Published - 5 Jun 2000
Externally published	Yes

Keywords

Cyclosporin-A
Experimental paraplegia
Free radicals
Inflammatory response
Lipid peroxidation
Methylprednisolone
Neuroprotection
Spinal cord injury
Survival

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10.1097/00001756-200006050-00033

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title = "Lipid peroxidation inhibition in spinal cord injury: Cyclosporin-A vs methylprednisolone",

abstract = "To compare the effectiveness of cyclosporin-A (CsA) with methylprednisolone (MP) or a combination of both upon inhibition of lipid peroxidation (LP) after spinal cord (SC) injury, rats were treated with either CsA, MP, CSA+MP or vehicle starting 1 h after SC contusion at T9 level. LP was assessed 24h after injury by the lipid fluorescent product formation method. The survival rate was also evaluated in other series of rats by the Kaplan-Meier curves. Lipid peroxidation was similarly inhibited in rats treated with CsA, MP, or CSA+MP (p > 0.05). Animals receiving MP (alone or combined with CsA) showed the poorest surviving rate. LP was inhibited by CsA to the same extent as by MP but without the lethal effect of the latter. (C) 2000 Lippincott Williams and Wilkins.",

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AU - Diaz-Ruiz, Aracell

AU - Rios, Camilo

AU - Duarte, Ivonne

AU - Correa, Dolores

AU - Guizar-Sahagun, Gabriel

AU - Grijalva, Israel

AU - Madrazo, Ignacio

AU - Ibarra, Antonio

PY - 2000/6/5

Y1 - 2000/6/5

N2 - To compare the effectiveness of cyclosporin-A (CsA) with methylprednisolone (MP) or a combination of both upon inhibition of lipid peroxidation (LP) after spinal cord (SC) injury, rats were treated with either CsA, MP, CSA+MP or vehicle starting 1 h after SC contusion at T9 level. LP was assessed 24h after injury by the lipid fluorescent product formation method. The survival rate was also evaluated in other series of rats by the Kaplan-Meier curves. Lipid peroxidation was similarly inhibited in rats treated with CsA, MP, or CSA+MP (p > 0.05). Animals receiving MP (alone or combined with CsA) showed the poorest surviving rate. LP was inhibited by CsA to the same extent as by MP but without the lethal effect of the latter. (C) 2000 Lippincott Williams and Wilkins.

AB - To compare the effectiveness of cyclosporin-A (CsA) with methylprednisolone (MP) or a combination of both upon inhibition of lipid peroxidation (LP) after spinal cord (SC) injury, rats were treated with either CsA, MP, CSA+MP or vehicle starting 1 h after SC contusion at T9 level. LP was assessed 24h after injury by the lipid fluorescent product formation method. The survival rate was also evaluated in other series of rats by the Kaplan-Meier curves. Lipid peroxidation was similarly inhibited in rats treated with CsA, MP, or CSA+MP (p > 0.05). Animals receiving MP (alone or combined with CsA) showed the poorest surviving rate. LP was inhibited by CsA to the same extent as by MP but without the lethal effect of the latter. (C) 2000 Lippincott Williams and Wilkins.

KW - Cyclosporin-A

KW - Experimental paraplegia

KW - Free radicals

KW - Inflammatory response

KW - Lipid peroxidation

KW - Methylprednisolone

KW - Neuroprotection

KW - Spinal cord injury

KW - Survival

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DO - 10.1097/00001756-200006050-00033

M3 - Artículo

C2 - 10852240

AN - SCOPUS:0034608570

SN - 0959-4965

VL - 11

SP - 1765

EP - 1767

JO - NeuroReport

JF - NeuroReport

IS - 8

ER -

Lipid peroxidation inhibition in spinal cord injury: Cyclosporin-A vs methylprednisolone

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Keywords

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