Neurogenesis after spinal cord injury: State of the art

Roxana Rodríguez-Barrera, Antonio Ibarra, Monserrat Rivas-González, Julián García-Sánchez, Daniel Mojica-Torres

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Neurogenesis in the adult state is the process of new neuron formation. This relatively infrequent phenomenon comprises four stages: cell proliferation, cell migration, differentiation, and the integration of these cells into an existing circuit. Recent reports suggest that neurogenesis can be found in different regions of the Central Nervous System (CNS), including the spinal cord (SC). This process can be observed in physiological settings; however, it is more evident in pathological conditions. After spinal cord injury (SCI), the activation of microglial cells and certain cytokines have shown to exert different modulatory effects depending on the presence of inflammation and on the specific region of the injury site. In these conditions, microglial cells and cytokines are considered to play an important role in the regulation of neurogenesis after SCI. The purpose of this article is to present an overview on neural progenitor cells and neurogenic and non-neurogenic zones as well as the cellular and molecular regulation of neurogenesis. Additionally, we will briefly describe the recent advances in the knowledge of neurogenesis after SCI.

Original languageEnglish
Article number1499
JournalCells
Volume10
Issue number6
DOIs
StatePublished - 1 Jun 2021

Keywords

  • Inflammation
  • Neurogenesis
  • SCI

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