Promoting of wakefulness by administrations of modafinil into anterior hypothalamus and into the pedunculopontine tegmental nucleus in rats

Eric Murillo-Rodríguez; Edgar Vázquez-Luis; Diana Millán-Aldaco; Reyes Haro; René Drucker-Colín

doi:10.1016/j.neulet.2008.03.048

Promoting of wakefulness by administrations of modafinil into anterior hypothalamus and into the pedunculopontine tegmental nucleus in rats

Eric Murillo-Rodríguez, Edgar Vázquez-Luis, Diana Millán-Aldaco, Reyes Haro, René Drucker-Colín

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We investigated whether administration of MOD in rats during the lights-on period into wake-promoting areas, such as anterior hypothalamus (AH) or into the pedunculopontine tegmental nucleus (PPTg) would enhance waking. Results showed that microinjections of 1 μL of MOD (10, 20, or 30 μg) into both brain areas increased the total time of alertness and decreased sleep. Additionally, MOD-treated rats showed an enhancement in alpha power spectra but delta power spectra was diminished. Finally, c-Fos expression was found increased into either AH or the PPTg. Collectively, these results suggest that MOD induces waking via the activity of two wake-related brain areas such as AH and the PPTg.

Original language	English
Pages (from-to)	283-287
Number of pages	5
Journal	Neuroscience Letters
Volume	436
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2008.03.048
State	Published - 9 May 2008
Externally published	Yes

Keywords

Alpha power spectra
Rapid eye movement sleep
Slow wave sleep
Waking

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10.1016/j.neulet.2008.03.048

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title = "Promoting of wakefulness by administrations of modafinil into anterior hypothalamus and into the pedunculopontine tegmental nucleus in rats",

abstract = "We investigated whether administration of MOD in rats during the lights-on period into wake-promoting areas, such as anterior hypothalamus (AH) or into the pedunculopontine tegmental nucleus (PPTg) would enhance waking. Results showed that microinjections of 1 μL of MOD (10, 20, or 30 μg) into both brain areas increased the total time of alertness and decreased sleep. Additionally, MOD-treated rats showed an enhancement in alpha power spectra but delta power spectra was diminished. Finally, c-Fos expression was found increased into either AH or the PPTg. Collectively, these results suggest that MOD induces waking via the activity of two wake-related brain areas such as AH and the PPTg.",

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AU - Murillo-Rodríguez, Eric

AU - Vázquez-Luis, Edgar

AU - Millán-Aldaco, Diana

AU - Haro, Reyes

AU - Drucker-Colín, René

PY - 2008/5/9

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N2 - We investigated whether administration of MOD in rats during the lights-on period into wake-promoting areas, such as anterior hypothalamus (AH) or into the pedunculopontine tegmental nucleus (PPTg) would enhance waking. Results showed that microinjections of 1 μL of MOD (10, 20, or 30 μg) into both brain areas increased the total time of alertness and decreased sleep. Additionally, MOD-treated rats showed an enhancement in alpha power spectra but delta power spectra was diminished. Finally, c-Fos expression was found increased into either AH or the PPTg. Collectively, these results suggest that MOD induces waking via the activity of two wake-related brain areas such as AH and the PPTg.

AB - We investigated whether administration of MOD in rats during the lights-on period into wake-promoting areas, such as anterior hypothalamus (AH) or into the pedunculopontine tegmental nucleus (PPTg) would enhance waking. Results showed that microinjections of 1 μL of MOD (10, 20, or 30 μg) into both brain areas increased the total time of alertness and decreased sleep. Additionally, MOD-treated rats showed an enhancement in alpha power spectra but delta power spectra was diminished. Finally, c-Fos expression was found increased into either AH or the PPTg. Collectively, these results suggest that MOD induces waking via the activity of two wake-related brain areas such as AH and the PPTg.

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Promoting of wakefulness by administrations of modafinil into anterior hypothalamus and into the pedunculopontine tegmental nucleus in rats

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Keywords

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