The hypolipidemic effect and antithrombotic activity of Mucuna pruriens protein hydrolysates

Francisco Herrera Chalé; Jorge Carlos Ruiz Ruiz; David Betancur Ancona; Juan José Acevedo Fernández; Maira Rubi Segura Campos

doi:10.1039/c5fo01012h

The hypolipidemic effect and antithrombotic activity of Mucuna pruriens protein hydrolysates

Francisco Herrera Chalé, Jorge Carlos Ruiz Ruiz, David Betancur Ancona, Juan José Acevedo Fernández, Maira Rubi Segura Campos

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Hydrolysates and peptide fractions (PF) obtained from M. pruriens protein concentrates with commercial and digestive enzymatic systems were studied for their hypolipidemic and antithrombotic activities. Hydrolysates obtained with Pepsin-Pancreatin (PP) and their peptide fractions inhibited cholesterol micellar solubility with a maximum value of 1.83% in PP. Wistar rats were used to evaluate the hypolipidemic effect of hydrolysates and PF. The higher reductions of cholesterol and triglyceride levels were exhibited by PP and both peptide fractions <1 kDa obtained from PP and Alcalase®-Flavourzyme® hydrolysate (AF) at a dose of 15 mg kg^-1 of animal weight. PF > 10 kDa from both hydrolysates showed the maximum antithrombotic activity with values of 33.33% for PF > 10 kDa from AF and 31.72% for PF > 10 kDa from PP. The results suggest that M. pruriens bioactive peptides with the hypolipidemic effect and antithrombotic activity might be utilized as nutraceuticals.

Original language	English
Pages (from-to)	434-444
Number of pages	11
Journal	Food and Function
Volume	7
Issue number	1
DOIs	https://doi.org/10.1039/c5fo01012h
State	Published - 1 Jan 2016
Externally published	Yes

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title = "The hypolipidemic effect and antithrombotic activity of Mucuna pruriens protein hydrolysates",

abstract = "Hydrolysates and peptide fractions (PF) obtained from M. pruriens protein concentrates with commercial and digestive enzymatic systems were studied for their hypolipidemic and antithrombotic activities. Hydrolysates obtained with Pepsin-Pancreatin (PP) and their peptide fractions inhibited cholesterol micellar solubility with a maximum value of 1.83\% in PP. Wistar rats were used to evaluate the hypolipidemic effect of hydrolysates and PF. The higher reductions of cholesterol and triglyceride levels were exhibited by PP and both peptide fractions <1 kDa obtained from PP and Alcalase{\textregistered}-Flavourzyme{\textregistered} hydrolysate (AF) at a dose of 15 mg kg-1 of animal weight. PF > 10 kDa from both hydrolysates showed the maximum antithrombotic activity with values of 33.33\% for PF > 10 kDa from AF and 31.72\% for PF > 10 kDa from PP. The results suggest that M. pruriens bioactive peptides with the hypolipidemic effect and antithrombotic activity might be utilized as nutraceuticals.",

author = "\{Herrera Chal{\'e}\}, Francisco and \{Ruiz Ruiz\}, \{Jorge Carlos\} and \{Betancur Ancona\}, David and \{Acevedo Fern{\'a}ndez\}, \{Juan Jos{\'e}\} and \{Segura Campos\}, \{Maira Rubi\}",

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doi = "10.1039/c5fo01012h",

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T1 - The hypolipidemic effect and antithrombotic activity of Mucuna pruriens protein hydrolysates

AU - Herrera Chalé, Francisco

AU - Ruiz Ruiz, Jorge Carlos

AU - Betancur Ancona, David

AU - Acevedo Fernández, Juan José

AU - Segura Campos, Maira Rubi

N1 - Publisher Copyright: © The Royal Society of Chemistry 2016.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Hydrolysates and peptide fractions (PF) obtained from M. pruriens protein concentrates with commercial and digestive enzymatic systems were studied for their hypolipidemic and antithrombotic activities. Hydrolysates obtained with Pepsin-Pancreatin (PP) and their peptide fractions inhibited cholesterol micellar solubility with a maximum value of 1.83% in PP. Wistar rats were used to evaluate the hypolipidemic effect of hydrolysates and PF. The higher reductions of cholesterol and triglyceride levels were exhibited by PP and both peptide fractions <1 kDa obtained from PP and Alcalase®-Flavourzyme® hydrolysate (AF) at a dose of 15 mg kg-1 of animal weight. PF > 10 kDa from both hydrolysates showed the maximum antithrombotic activity with values of 33.33% for PF > 10 kDa from AF and 31.72% for PF > 10 kDa from PP. The results suggest that M. pruriens bioactive peptides with the hypolipidemic effect and antithrombotic activity might be utilized as nutraceuticals.

AB - Hydrolysates and peptide fractions (PF) obtained from M. pruriens protein concentrates with commercial and digestive enzymatic systems were studied for their hypolipidemic and antithrombotic activities. Hydrolysates obtained with Pepsin-Pancreatin (PP) and their peptide fractions inhibited cholesterol micellar solubility with a maximum value of 1.83% in PP. Wistar rats were used to evaluate the hypolipidemic effect of hydrolysates and PF. The higher reductions of cholesterol and triglyceride levels were exhibited by PP and both peptide fractions <1 kDa obtained from PP and Alcalase®-Flavourzyme® hydrolysate (AF) at a dose of 15 mg kg-1 of animal weight. PF > 10 kDa from both hydrolysates showed the maximum antithrombotic activity with values of 33.33% for PF > 10 kDa from AF and 31.72% for PF > 10 kDa from PP. The results suggest that M. pruriens bioactive peptides with the hypolipidemic effect and antithrombotic activity might be utilized as nutraceuticals.

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U2 - 10.1039/c5fo01012h

DO - 10.1039/c5fo01012h

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AN - SCOPUS:84956695873

SN - 2042-6496

VL - 7

SP - 434

EP - 444

JO - Food and Function

JF - Food and Function

IS - 1

ER -

The hypolipidemic effect and antithrombotic activity of Mucuna pruriens protein hydrolysates

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