The Nonpsychoactive Cannabis Constituent Cannabidiol Is a Wake-Inducing Agent

Eric Murillo-Rodríguez; Diana Millán-Aldaco; Marcela Palomero-Rivero; Raphael Mechoulam; René Drucker-Colín

doi:10.1037/a0013278

The Nonpsychoactive Cannabis Constituent Cannabidiol Is a Wake-Inducing Agent

Eric Murillo-Rodríguez, Diana Millán-Aldaco, Marcela Palomero-Rivero, Raphael Mechoulam, René Drucker-Colín

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Cannabidiol (CBD) is a constituent of Cannabis sativa that induces nonpsychotropic effects, and some of its biological actions in sleep have been described by the authors' group. Here, the authors report that when administered 10 or 20 μg/1 μl during the lights-on period directly into either lateral hypothalamus (LH) or dorsal raphe nuclei (DRN), which are wake-inducing brain areas, CBD enhanced wakefulness and decreased slow wave sleep and REM sleep. Furthermore, CBD increased alpha and theta power spectra but diminished delta power spectra. Additionally, CBD increased c-Fos expression in LH or DRN. These findings suggest that this cannabinoid is a wake-inducing compound that presumably activates neurons in LH and DRN.

Original language	English
Pages (from-to)	1378-1382
Number of pages	5
Journal	Behavioral Neuroscience
Volume	122
Issue number	6
DOIs	https://doi.org/10.1037/a0013278
State	Published - 1 Dec 2008
Externally published	Yes

Keywords

cannabinoid receptor
delta power spectra
insomnia
slow wave sleep
wakefulness

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10.1037/a0013278

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abstract = "Cannabidiol (CBD) is a constituent of Cannabis sativa that induces nonpsychotropic effects, and some of its biological actions in sleep have been described by the authors' group. Here, the authors report that when administered 10 or 20 μg/1 μl during the lights-on period directly into either lateral hypothalamus (LH) or dorsal raphe nuclei (DRN), which are wake-inducing brain areas, CBD enhanced wakefulness and decreased slow wave sleep and REM sleep. Furthermore, CBD increased alpha and theta power spectra but diminished delta power spectra. Additionally, CBD increased c-Fos expression in LH or DRN. These findings suggest that this cannabinoid is a wake-inducing compound that presumably activates neurons in LH and DRN.",

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AU - Drucker-Colín, René

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The Nonpsychoactive Cannabis Constituent Cannabidiol Is a Wake-Inducing Agent

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Keywords

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