TY - GEN
T1 - Tunable Isotropic TPMS-Based 3D-Architected Scaffolds for Diabetic Bone Regeneration
AU - Morales-Gómez, Fátima
AU - Hernández-Rosas, Fabiola
AU - Zapatero-Gutiérrez, Araceli
AU - Ramírez-Cedillo, Erick
AU - García-Ávila, Josué
N1 - Publisher Copyright:
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.
PY - 2025/1/1
Y1 - 2025/1/1
N2 - Diabetes mellitus significantly compromises bone health, increasing the risk of fractures, osteoporosis, and limb amputations due to metabolic dysfunctions. Effective bone regeneration is critical for managing complex fractures and bone-related complications, with over two million bone grafts performed annually. This research focuses on designing and developing personalized 3D-architected scaffolds to enhance bone regeneration in patients with diabetes using computational simulation techniques. These scaffolds are tailored to replicate the mechanical and structural properties of natural bone by optimizing key features such as anisotropy, porosity, and nutrient mass flow. The study highlights the transformative potential of personalized 3D-architected scaffolds in addressing critical challenges associated with diabetic bone health. Customizing scaffold designs to meet the specific needs of patients with diabetes aims to reduce postoperative complications, improve healing outcomes, and enhance overall patient quality of life. Future work will refine scaffold designs and validate their performance in diabetes-specific clinical in vitro and in vivo models.
AB - Diabetes mellitus significantly compromises bone health, increasing the risk of fractures, osteoporosis, and limb amputations due to metabolic dysfunctions. Effective bone regeneration is critical for managing complex fractures and bone-related complications, with over two million bone grafts performed annually. This research focuses on designing and developing personalized 3D-architected scaffolds to enhance bone regeneration in patients with diabetes using computational simulation techniques. These scaffolds are tailored to replicate the mechanical and structural properties of natural bone by optimizing key features such as anisotropy, porosity, and nutrient mass flow. The study highlights the transformative potential of personalized 3D-architected scaffolds in addressing critical challenges associated with diabetic bone health. Customizing scaffold designs to meet the specific needs of patients with diabetes aims to reduce postoperative complications, improve healing outcomes, and enhance overall patient quality of life. Future work will refine scaffold designs and validate their performance in diabetes-specific clinical in vitro and in vivo models.
KW - Bone Regeneration
KW - Diabetes Mellitus
KW - Scaffold
UR - https://www.scopus.com/pages/publications/105010211545
U2 - 10.1007/978-3-031-96538-8_23
DO - 10.1007/978-3-031-96538-8_23
M3 - Contribución a la conferencia
AN - SCOPUS:105010211545
SN - 9783031965371
T3 - IFMBE Proceedings
SP - 278
EP - 285
BT - Joint 20th Nordic-Baltic Conference on Biomedical Engineering and 24th Polish Conference on Biocybernetics and Biomedical Engineering - Joint Proceedings of NBC 2025 and PCBBE 2025
A2 - Ladyzynski, Piotr
A2 - Pijanowska, Dorota G.
A2 - Liebert, Adam
PB - Springer Science and Business Media Deutschland GmbH
T2 - Joint 20th Nordic-Baltic Conference on Biomedical Engineering and 24th Polish Conference on Biocybernetics and Biomedical Engineering, NBC 2025 and PCBBE 2025
Y2 - 16 June 2025 through 18 June 2025
ER -