Uncovering the muscle clock–mitochondria axis through exercise

Mauricio Castro-Sepulveda

doi:10.1016/j.tem.2025.11.001

Uncovering the muscle clock–mitochondria axis through exercise

Mauricio Castro-Sepulveda^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey

Abstract

Emerging evidence suggests an interplay between the molecular clock and mitochondrial dynamics in skeletal muscle. In this Forum article, we hypothesize that exercise, as a metabolic challenge, provides a powerful physiological model to investigate the clock–mitochondria axis and its regulatory role in muscle function and metabolic health in humans.

Original language	English
Pages (from-to)	4-7
Number of pages	4
Journal	Trends in Endocrinology and Metabolism
Volume	37
Issue number	1
DOIs	https://doi.org/10.1016/j.tem.2025.11.001
State	Published - 1 Jan 2026

Keywords

circadian clock
insulin resistance
mitochondrial dynamics
muscle atrophy

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10.1016/j.tem.2025.11.001

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title = "Uncovering the muscle clock–mitochondria axis through exercise",

abstract = "Emerging evidence suggests an interplay between the molecular clock and mitochondrial dynamics in skeletal muscle. In this Forum article, we hypothesize that exercise, as a metabolic challenge, provides a powerful physiological model to investigate the clock–mitochondria axis and its regulatory role in muscle function and metabolic health in humans.",

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AB - Emerging evidence suggests an interplay between the molecular clock and mitochondrial dynamics in skeletal muscle. In this Forum article, we hypothesize that exercise, as a metabolic challenge, provides a powerful physiological model to investigate the clock–mitochondria axis and its regulatory role in muscle function and metabolic health in humans.

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KW - insulin resistance

KW - mitochondrial dynamics

KW - muscle atrophy

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Uncovering the muscle clock–mitochondria axis through exercise

Abstract

Keywords

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