TY - JOUR
T1 - Active Surveillance of Antimicrobial Resistance and Carbapenemase-Encoding Genes According to Sites of Care and Age Groups in Mexico
T2 - Results from the INVIFAR Network
AU - Rojas-Larios, Fabian
AU - Martínez-Guerra, Bernardo Alfonso
AU - López-Jácome, Luis Esaú
AU - Bolado-Martínez, Enrique
AU - Vázquez-Larios, María del Rosario
AU - Velázquez-Acosta, María del Consuelo
AU - Romero-Romero, Daniel
AU - Mireles-Dávalos, Christian Daniel
AU - Quintana-Ponce, Sandra
AU - Feliciano-Guzmán, José Manuel
AU - Pérez-Hernandez, José Miguel
AU - Correa-León, Yoselin Paola
AU - López-Gutiérrez, Eduardo
AU - Rodriguez-Noriega, Eduardo
AU - González-Díaz, Esteban
AU - Choy-Chang, Elena Victoria
AU - Mena-Ramírez, Juan Pablo
AU - Monroy-Colín, Víctor Antonio
AU - Ponce-de-León-Garduño, Alfredo
AU - Alcaraz-Espejel, Margarita
AU - Avilés-Benítez, Laura Karina
AU - Quintanilla-Cazares, Luís Javier
AU - Ramírez-Alanís, Eloisa
AU - Barajas-Magallón, Juan Manuel
AU - Padilla-Ibarra, Cecilia
AU - Ballesteros-Silva, Maria Bertha
AU - Atanacio-Sixto, Noe Antonio
AU - Morales-de-la-Peña, Cecilia Teresita
AU - Galindo-Méndez, Mario
AU - Pérez-Vicelis, Talía
AU - Jacobo-Baca, Guillermo
AU - Moreno-Méndez, Martha Irene
AU - Mora-Pacheco, María de la Luz
AU - Gutiérrez-Brito, Maricruz
AU - Sánchez-Godínez, Xochitl Yadira
AU - Navarro-Vargas, Norberta Vianey
AU - Mercado-Bravo, Luz Elena
AU - Delgado-Barrientos, Alejandro
AU - Santiago-Calderón, María Asunción
AU - López-Ovilla, Ismelda
AU - Molina-Chavarria, Alejandro
AU - Rincón-Zuno, Joaquín
AU - Franco-Cendejas, Rafael
AU - Miranda-Mauricio, Sandra
AU - Márquez-Avalos, Isabel Cristina
AU - López-García, Maribel
AU - Duarte-Miranda, Lizbeth Soraya
AU - Cetina-Umaña, Carlos Miguel
AU - Barroso-Herrera-y-Cairo, Irma Elena
AU - López-Moreno, Laura Isabel
AU - Garza-González, Elvira
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/9/1
Y1 - 2023/9/1
N2 - We analyzed the antimicrobial resistance (AMR) data of 6519 clinical isolates of Escherichia coli (n = 3985), Klebsiella pneumoniae (n = 775), Acinetobacter baumannii (n = 163), Pseudomonas aeruginosa (n = 781), Enterococcus faecium (n = 124), and Staphylococcus aureus (n = 691) from 43 centers in Mexico. AMR assays were performed using commercial microdilution systems (37/43) and the disk diffusion susceptibility method (6/43). The presence of carbapenemase-encoding genes was assessed using PCR. Data from centers regarding site of care, patient age, and clinical specimen were collected. According to the site of care, the highest AMR was observed in E. coli, K. pneumoniae, and P. aeruginosa isolates from ICU patients. In contrast, in A. baumannii, higher AMR was observed in isolates from hospitalized non-ICU patients. According to age group, the highest AMR was observed in the ≥60 years age group for E. coli, E. faecium, and S. aureus, and in the 19–59 years age group for A. baumannii and P. aeruginosa. According to clinical specimen type, a higher AMR was observed in E. coli, K. pneumoniae, and P. aeruginosa isolates from blood specimens. The most frequently detected carbapenemase-encoding gene in E. coli was blaNDM (84%).
AB - We analyzed the antimicrobial resistance (AMR) data of 6519 clinical isolates of Escherichia coli (n = 3985), Klebsiella pneumoniae (n = 775), Acinetobacter baumannii (n = 163), Pseudomonas aeruginosa (n = 781), Enterococcus faecium (n = 124), and Staphylococcus aureus (n = 691) from 43 centers in Mexico. AMR assays were performed using commercial microdilution systems (37/43) and the disk diffusion susceptibility method (6/43). The presence of carbapenemase-encoding genes was assessed using PCR. Data from centers regarding site of care, patient age, and clinical specimen were collected. According to the site of care, the highest AMR was observed in E. coli, K. pneumoniae, and P. aeruginosa isolates from ICU patients. In contrast, in A. baumannii, higher AMR was observed in isolates from hospitalized non-ICU patients. According to age group, the highest AMR was observed in the ≥60 years age group for E. coli, E. faecium, and S. aureus, and in the 19–59 years age group for A. baumannii and P. aeruginosa. According to clinical specimen type, a higher AMR was observed in E. coli, K. pneumoniae, and P. aeruginosa isolates from blood specimens. The most frequently detected carbapenemase-encoding gene in E. coli was blaNDM (84%).
KW - INVIFAR
KW - MRSA
KW - VRE
KW - antimicrobial resistance
KW - carbapenem-resistance
UR - https://www.scopus.com/pages/publications/85172934467
U2 - 10.3390/pathogens12091144
DO - 10.3390/pathogens12091144
M3 - Artículo
AN - SCOPUS:85172934467
SN - 2076-0817
VL - 12
JO - Pathogens
JF - Pathogens
IS - 9
M1 - 1144
ER -