Early effects of modulating nuclear factor-κB activation on traumatic spinal cord injury in rats

Octavio Jiménez-Garza; Javier Camacho; Antonio Ibarra; Angelina Martínez; Gabriel Guízar-Sahagún

doi:10.1196/annals.1344.012

Early effects of modulating nuclear factor-κB activation on traumatic spinal cord injury in rats

Octavio Jiménez-Garza
, Javier Camacho
, Antonio Ibarra
, Angelina Martínez
, Gabriel Guízar-Sahagún^*

^*Autor correspondiente de este trabajo

Centro de Investigacion y de Estudios Avanzados del Instituto Politécnico Nacional
Instituto Mexicano del Seguro Social

Producción científica: Contribución a una revista › Artículo

16 Citas (Scopus)

Resumen

Genes regulated by NF-κB play an important role on secondary damage and repair after spinal cord injury (SCI). To assess the early effects of the pharmacological inhibition and overactivation of NF-κB, pyrrolidine dithiocarbamate (PDTC) or lipopolysaccharide were given to rats before or after SC contusion. The amount of spared SC tissue was higher (P < 0.05) at 24 h postinjury in rats posttreated with PDTC; both PDTC-treated rats showed no significant trend to decrease polymorphonuclear infiltrate. p65 subunit was present in inflammatory cells, neurons, and astrocytes at the injury site. These data support further investigation on functional effects of NF-κB inhibition in acute SCI.

Idioma original	Inglés
Páginas (desde-hasta)	148-150
Número de páginas	3
Publicación	Annals of the New York Academy of Sciences
Volumen	1053
DOI	https://doi.org/10.1196/annals.1344.012
Estado	Publicada - 1 ene 2005
Publicado de forma externa	Sí

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title = "Early effects of modulating nuclear factor-κB activation on traumatic spinal cord injury in rats",

abstract = "Genes regulated by NF-κB play an important role on secondary damage and repair after spinal cord injury (SCI). To assess the early effects of the pharmacological inhibition and overactivation of NF-κB, pyrrolidine dithiocarbamate (PDTC) or lipopolysaccharide were given to rats before or after SC contusion. The amount of spared SC tissue was higher (P < 0.05) at 24 h postinjury in rats posttreated with PDTC; both PDTC-treated rats showed no significant trend to decrease polymorphonuclear infiltrate. p65 subunit was present in inflammatory cells, neurons, and astrocytes at the injury site. These data support further investigation on functional effects of NF-κB inhibition in acute SCI.",

keywords = "Inflammation, Lipopolysaccharide, Nuclear factor-κB (NF-κB), Pyrrolidine dithiocarbamate, Spared tissue, Spinal cord injury (SCI)",

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TY - JOUR

T1 - Early effects of modulating nuclear factor-κB activation on traumatic spinal cord injury in rats

AU - Jiménez-Garza, Octavio

AU - Camacho, Javier

AU - Ibarra, Antonio

AU - Martínez, Angelina

AU - Guízar-Sahagún, Gabriel

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Genes regulated by NF-κB play an important role on secondary damage and repair after spinal cord injury (SCI). To assess the early effects of the pharmacological inhibition and overactivation of NF-κB, pyrrolidine dithiocarbamate (PDTC) or lipopolysaccharide were given to rats before or after SC contusion. The amount of spared SC tissue was higher (P < 0.05) at 24 h postinjury in rats posttreated with PDTC; both PDTC-treated rats showed no significant trend to decrease polymorphonuclear infiltrate. p65 subunit was present in inflammatory cells, neurons, and astrocytes at the injury site. These data support further investigation on functional effects of NF-κB inhibition in acute SCI.

AB - Genes regulated by NF-κB play an important role on secondary damage and repair after spinal cord injury (SCI). To assess the early effects of the pharmacological inhibition and overactivation of NF-κB, pyrrolidine dithiocarbamate (PDTC) or lipopolysaccharide were given to rats before or after SC contusion. The amount of spared SC tissue was higher (P < 0.05) at 24 h postinjury in rats posttreated with PDTC; both PDTC-treated rats showed no significant trend to decrease polymorphonuclear infiltrate. p65 subunit was present in inflammatory cells, neurons, and astrocytes at the injury site. These data support further investigation on functional effects of NF-κB inhibition in acute SCI.

KW - Inflammation

KW - Lipopolysaccharide

KW - Nuclear factor-κB (NF-κB)

KW - Pyrrolidine dithiocarbamate

KW - Spared tissue

KW - Spinal cord injury (SCI)

UR - https://www.scopus.com/pages/publications/29744458521

U2 - 10.1196/annals.1344.012

DO - 10.1196/annals.1344.012

M3 - Artículo

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AN - SCOPUS:29744458521

SN - 0077-8923

VL - 1053

SP - 148

EP - 150

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Early effects of modulating nuclear factor-κB activation on traumatic spinal cord injury in rats

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