Modafinil enhances extracellular levels of dopamine in the nucleus accumbens and increases wakefulness in rats

Eric Murillo-Rodríguez; Reyes Haro; Marcela Palomero-Rivero; Diana Millán-Aldaco; René Drucker-Colín

doi:10.1016/j.bbr.2006.10.016

Modafinil enhances extracellular levels of dopamine in the nucleus accumbens and increases wakefulness in rats

Eric Murillo-Rodríguez^*
, Reyes Haro
, Marcela Palomero-Rivero
, Diana Millán-Aldaco
, René Drucker-Colín

^*Autor correspondiente de este trabajo

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

82 Citas (Scopus)

Resumen

Modafinil (MOD) is a wakefulness-promoting drug that improves the alertness levels in narcolepsy; however, the molecular mechanism of action remains to be elucidated. We found that after a single icv injection of MOD (10 μg/5 μl) the extracellular levels of dopamine (DA) and l-DOPA collected from the nucleus accumbens were increased and decreased, respectively. Separately, the icv administration of MOD (10 μg/5 μl) to rats enhanced wakefulness (W) whereas diminished sleep during 4 h. Lastly, the alertness induced by MOD was partially antagonized by the sleep-inducing endocannabinoid anandamide (ANA). We conclude that MOD enhances the extracellular levels of DA, promotes W and its effects on sleep are partially blocked by ANA.

Idioma original	Inglés
Páginas (desde-hasta)	353-357
Número de páginas	5
Publicación	Behavioural Brain Research
Volumen	176
N.º	2
DOI	https://doi.org/10.1016/j.bbr.2006.10.016
Estado	Publicada - 25 ene 2007
Publicado de forma externa	Sí

Acceder al documento

10.1016/j.bbr.2006.10.016

Otros archivos y enlaces

Enlace a la publicación en Scopus

Citar esto

@article{3bbf9ff7eff445e383bed1ccd33ebba6,

title = "Modafinil enhances extracellular levels of dopamine in the nucleus accumbens and increases wakefulness in rats",

abstract = "Modafinil (MOD) is a wakefulness-promoting drug that improves the alertness levels in narcolepsy; however, the molecular mechanism of action remains to be elucidated. We found that after a single icv injection of MOD (10 μg/5 μl) the extracellular levels of dopamine (DA) and l-DOPA collected from the nucleus accumbens were increased and decreased, respectively. Separately, the icv administration of MOD (10 μg/5 μl) to rats enhanced wakefulness (W) whereas diminished sleep during 4 h. Lastly, the alertness induced by MOD was partially antagonized by the sleep-inducing endocannabinoid anandamide (ANA). We conclude that MOD enhances the extracellular levels of DA, promotes W and its effects on sleep are partially blocked by ANA.",

keywords = "Dopamine, Endocannabinoid, Microdialysis, Modafinil, Sleep, Waking",

author = "Eric Murillo-Rodr{\'i}guez and Reyes Haro and Marcela Palomero-Rivero and Diana Mill{\'a}n-Aldaco and Ren{\'e} Drucker-Col{\'i}n",

year = "2007",

month = jan,

day = "25",

doi = "10.1016/j.bbr.2006.10.016",

language = "Ingl{\'e}s",

volume = "176",

pages = "353--357",

journal = "Behavioural Brain Research",

issn = "0166-4328",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Modafinil enhances extracellular levels of dopamine in the nucleus accumbens and increases wakefulness in rats

AU - Murillo-Rodríguez, Eric

AU - Haro, Reyes

AU - Palomero-Rivero, Marcela

AU - Millán-Aldaco, Diana

AU - Drucker-Colín, René

PY - 2007/1/25

Y1 - 2007/1/25

N2 - Modafinil (MOD) is a wakefulness-promoting drug that improves the alertness levels in narcolepsy; however, the molecular mechanism of action remains to be elucidated. We found that after a single icv injection of MOD (10 μg/5 μl) the extracellular levels of dopamine (DA) and l-DOPA collected from the nucleus accumbens were increased and decreased, respectively. Separately, the icv administration of MOD (10 μg/5 μl) to rats enhanced wakefulness (W) whereas diminished sleep during 4 h. Lastly, the alertness induced by MOD was partially antagonized by the sleep-inducing endocannabinoid anandamide (ANA). We conclude that MOD enhances the extracellular levels of DA, promotes W and its effects on sleep are partially blocked by ANA.

AB - Modafinil (MOD) is a wakefulness-promoting drug that improves the alertness levels in narcolepsy; however, the molecular mechanism of action remains to be elucidated. We found that after a single icv injection of MOD (10 μg/5 μl) the extracellular levels of dopamine (DA) and l-DOPA collected from the nucleus accumbens were increased and decreased, respectively. Separately, the icv administration of MOD (10 μg/5 μl) to rats enhanced wakefulness (W) whereas diminished sleep during 4 h. Lastly, the alertness induced by MOD was partially antagonized by the sleep-inducing endocannabinoid anandamide (ANA). We conclude that MOD enhances the extracellular levels of DA, promotes W and its effects on sleep are partially blocked by ANA.

KW - Dopamine

KW - Endocannabinoid

KW - Microdialysis

KW - Modafinil

KW - Sleep

KW - Waking

UR - https://www.scopus.com/pages/publications/33845426470

U2 - 10.1016/j.bbr.2006.10.016

DO - 10.1016/j.bbr.2006.10.016

M3 - Artículo

C2 - 17098298

AN - SCOPUS:33845426470

SN - 0166-4328

VL - 176

SP - 353

EP - 357

JO - Behavioural Brain Research

JF - Behavioural Brain Research

IS - 2

ER -

Modafinil enhances extracellular levels of dopamine in the nucleus accumbens and increases wakefulness in rats

Resumen

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto