TY - JOUR
T1 - ACE inhibitory, hypotensive and antioxidant peptide fractions from Mucuna pruriens proteins
AU - Herrera Chalé, Francisco Gilberto
AU - Ruiz Ruiz, Jorge Carlos
AU - Acevedo Fernández, Juan José
AU - Betancur Ancona, David Abram
AU - Segura Campos, Maira Rubi
N1 - Publisher Copyright:
© 2014 Elsevier Ltd.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Hydrolysates and peptide fractions obtained from Mucuna pruriens protein concentrate were studied for their angiotensin converting enzyme (ACE) inhibitory, hypotensive and antioxidant activities. The hydrolysate obtained by pepsin-pancreatin (HPP) was the most active with an ACE IC50 value of 19.5 μg/mL, a Trolox equivalent antioxidant capacity (TEAC) value of 102.8 mM/mg and a ferric reducing power (FRP) IC50 of 67.2 μg/mL. At a dose of 5 mg/kg HPP decrease systolic (32.2%) and diastolic (37%) blood pressure in rats more pronounced than Captopril. The peptide fraction <1 kDa from HPP was the most active with an ACE inhibitory of 10.2 μg/mL (IC50), a TEAC value of 709.8 mM/mg and a FRP IC50 of 54.9 μg/mL. These results indicate that the hydrolysates and peptide fractions of M. pruriens would be used as nutraceuticals ingredients for preventing and providing therapy against hypertension and diseases related to oxidative damage.
AB - Hydrolysates and peptide fractions obtained from Mucuna pruriens protein concentrate were studied for their angiotensin converting enzyme (ACE) inhibitory, hypotensive and antioxidant activities. The hydrolysate obtained by pepsin-pancreatin (HPP) was the most active with an ACE IC50 value of 19.5 μg/mL, a Trolox equivalent antioxidant capacity (TEAC) value of 102.8 mM/mg and a ferric reducing power (FRP) IC50 of 67.2 μg/mL. At a dose of 5 mg/kg HPP decrease systolic (32.2%) and diastolic (37%) blood pressure in rats more pronounced than Captopril. The peptide fraction <1 kDa from HPP was the most active with an ACE inhibitory of 10.2 μg/mL (IC50), a TEAC value of 709.8 mM/mg and a FRP IC50 of 54.9 μg/mL. These results indicate that the hydrolysates and peptide fractions of M. pruriens would be used as nutraceuticals ingredients for preventing and providing therapy against hypertension and diseases related to oxidative damage.
KW - Antioxidant
KW - Hydrolysates
KW - Hypotensive
KW - Mucuna pruriens
KW - Peptide fractions
UR - https://www.scopus.com/pages/publications/84908702221
U2 - 10.1016/j.procbio.2014.06.021
DO - 10.1016/j.procbio.2014.06.021
M3 - Artículo
AN - SCOPUS:84908702221
SN - 1359-5113
VL - 49
SP - 1691
EP - 1698
JO - Process Biochemistry
JF - Process Biochemistry
IS - 10
ER -