Development and characterization of nanocapsules comprising dodecyltrimethylammonium chloride and κ-carrageenan

A. Rosas-Durazo; J. Lizardi; I. Higuera-Ciapara; W. Argüelles-Monal; F. M. Goycoolea

doi:10.1016/j.colsurfb.2011.03.020

Development and characterization of nanocapsules comprising dodecyltrimethylammonium chloride and κ-carrageenan

A. Rosas-Durazo
, J. Lizardi
, I. Higuera-Ciapara
, W. Argüelles-Monal
, F. M. Goycoolea^*

^*Autore corrispondente per questo lavoro

Risultato della ricerca › peer review

14 Citazioni (Scopus)

Abstract

The aim of this work was to develop and characterize a new type of nanocapsules. To this end, a nanoemulsion bearing an oily core (Miglyol 812) was obtained by spontaneous emulsification and stabilized by dodecyl-trimethylammonium chloride (DTAC), a commercial cationic surfactant; this nanoemulsion was coated with proportionally very small amounts of κ-carrageenan (at molar charge ratios of Z≤ 0.0045) that interact predominantly by an electrostatic mechanism with the positively charged sites at the polar heads of DTAC at the nanoemulsion's surface to harness nanocapsules of average size ∼250-330. nm and zeta potential (ζ) ranging from ∼+80 to +7. mV. The potential application of the new type of developed nanosystems as drug delivery vehicles has yet to be investigated and fully realized.

Lingua originale	English
pagine (da-a)	242-246
Numero di pagine	5
Rivista	Colloids and Surfaces B: Biointerfaces
Volume	86
Numero di pubblicazione	1
DOI	https://doi.org/10.1016/j.colsurfb.2011.03.020
Stato di pubblicazione	Published - 1 ago 2011
Pubblicato esternamente	Sì

Accesso al documento

10.1016/j.colsurfb.2011.03.020

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https://www.scopus.com/pages/publications/79955854641

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title = "Development and characterization of nanocapsules comprising dodecyltrimethylammonium chloride and κ-carrageenan",

abstract = "The aim of this work was to develop and characterize a new type of nanocapsules. To this end, a nanoemulsion bearing an oily core (Miglyol 812) was obtained by spontaneous emulsification and stabilized by dodecyl-trimethylammonium chloride (DTAC), a commercial cationic surfactant; this nanoemulsion was coated with proportionally very small amounts of κ-carrageenan (at molar charge ratios of Z≤ 0.0045) that interact predominantly by an electrostatic mechanism with the positively charged sites at the polar heads of DTAC at the nanoemulsion's surface to harness nanocapsules of average size ∼250-330. nm and zeta potential (ζ) ranging from ∼+80 to +7. mV. The potential application of the new type of developed nanosystems as drug delivery vehicles has yet to be investigated and fully realized.",

keywords = "Carrageenan, Dodecyltrimethylammonium chloride, Nanocapsules",

author = "A. Rosas-Durazo and J. Lizardi and I. Higuera-Ciapara and W. Arg{\"u}elles-Monal and Goycoolea, \{F. M.\}",

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T1 - Development and characterization of nanocapsules comprising dodecyltrimethylammonium chloride and κ-carrageenan

AU - Rosas-Durazo, A.

AU - Lizardi, J.

AU - Higuera-Ciapara, I.

AU - Argüelles-Monal, W.

AU - Goycoolea, F. M.

PY - 2011/8/1

Y1 - 2011/8/1

N2 - The aim of this work was to develop and characterize a new type of nanocapsules. To this end, a nanoemulsion bearing an oily core (Miglyol 812) was obtained by spontaneous emulsification and stabilized by dodecyl-trimethylammonium chloride (DTAC), a commercial cationic surfactant; this nanoemulsion was coated with proportionally very small amounts of κ-carrageenan (at molar charge ratios of Z≤ 0.0045) that interact predominantly by an electrostatic mechanism with the positively charged sites at the polar heads of DTAC at the nanoemulsion's surface to harness nanocapsules of average size ∼250-330. nm and zeta potential (ζ) ranging from ∼+80 to +7. mV. The potential application of the new type of developed nanosystems as drug delivery vehicles has yet to be investigated and fully realized.

AB - The aim of this work was to develop and characterize a new type of nanocapsules. To this end, a nanoemulsion bearing an oily core (Miglyol 812) was obtained by spontaneous emulsification and stabilized by dodecyl-trimethylammonium chloride (DTAC), a commercial cationic surfactant; this nanoemulsion was coated with proportionally very small amounts of κ-carrageenan (at molar charge ratios of Z≤ 0.0045) that interact predominantly by an electrostatic mechanism with the positively charged sites at the polar heads of DTAC at the nanoemulsion's surface to harness nanocapsules of average size ∼250-330. nm and zeta potential (ζ) ranging from ∼+80 to +7. mV. The potential application of the new type of developed nanosystems as drug delivery vehicles has yet to be investigated and fully realized.

KW - Carrageenan

KW - Dodecyltrimethylammonium chloride

KW - Nanocapsules

UR - https://www.scopus.com/pages/publications/79955854641

U2 - 10.1016/j.colsurfb.2011.03.020

DO - 10.1016/j.colsurfb.2011.03.020

M3 - Artículo

C2 - 21497069

AN - SCOPUS:79955854641

SN - 0927-7765

VL - 86

SP - 242

EP - 246

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

IS - 1

ER -

Development and characterization of nanocapsules comprising dodecyltrimethylammonium chloride and κ-carrageenan

Abstract

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