Development of post-traumatic cysts in the spinal cord of rats subjected to severe spinal cord contusion

Gabriel Guizar-Sahagun; Israel Grijalva; Ignacio Madrazo; Rebecca Franco-Bourland; Hermelinda Salgado; Antonio Ibarra; Elena Oliva; Armando Zepeda

doi:10.1016/0090-3019(94)90131-7

Development of post-traumatic cysts in the spinal cord of rats subjected to severe spinal cord contusion

Gabriel Guizar-Sahagun
, Israel Grijalva
, Ignacio Madrazo^*
, Rebecca Franco-Bourland
, Hermelinda Salgado
, Antonio Ibarra
, Elena Oliva
, Armando Zepeda

^*Autore corrispondente per questo lavoro

Risultato della ricerca › peer review

74 Citazioni (Scopus)

Abstract

To study the development of post-traumatic spinal cord (SC) cysts, and their fine anatomic characteristics, rats were subjected to severe SC contusion. Specimens were analyzed from day 1 to 1 year post-injury. Using conventional light, and transmission and scanning electron microscopy, three stages were typified, namely: necrosis, repair, and stability. The final cell composition and thickness of the cyst walls were not uniform. Astrocytes, fibroblasts, ependymal cells, and collagen fibers were the main constituents. Chronic inflammatory cells were also observed. The neuropathologic characterization of post-traumatic SC cysts could be useful in planning strategies for SC reconstruction at different times post-injury.

Lingua originale	English
pagine (da-a)	241-249
Numero di pagine	9
Rivista	Surgical Neurology
Volume	41
Numero di pubblicazione	3
DOI	https://doi.org/10.1016/0090-3019(94)90131-7
Stato di pubblicazione	Published - 1 gen 1994
Pubblicato esternamente	Sì

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10.1016/0090-3019(94)90131-7

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https://www.scopus.com/pages/publications/0028228366

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title = "Development of post-traumatic cysts in the spinal cord of rats subjected to severe spinal cord contusion",

abstract = "To study the development of post-traumatic spinal cord (SC) cysts, and their fine anatomic characteristics, rats were subjected to severe SC contusion. Specimens were analyzed from day 1 to 1 year post-injury. Using conventional light, and transmission and scanning electron microscopy, three stages were typified, namely: necrosis, repair, and stability. The final cell composition and thickness of the cyst walls were not uniform. Astrocytes, fibroblasts, ependymal cells, and collagen fibers were the main constituents. Chronic inflammatory cells were also observed. The neuropathologic characterization of post-traumatic SC cysts could be useful in planning strategies for SC reconstruction at different times post-injury.",

keywords = "Experimental spinal cord injury, Paraplegia, Post-traumatic cysts, Spinal cord contusion",

author = "Gabriel Guizar-Sahagun and Israel Grijalva and Ignacio Madrazo and Rebecca Franco-Bourland and Hermelinda Salgado and Antonio Ibarra and Elena Oliva and Armando Zepeda",

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T1 - Development of post-traumatic cysts in the spinal cord of rats subjected to severe spinal cord contusion

AU - Guizar-Sahagun, Gabriel

AU - Grijalva, Israel

AU - Madrazo, Ignacio

AU - Franco-Bourland, Rebecca

AU - Salgado, Hermelinda

AU - Ibarra, Antonio

AU - Oliva, Elena

AU - Zepeda, Armando

PY - 1994/1/1

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N2 - To study the development of post-traumatic spinal cord (SC) cysts, and their fine anatomic characteristics, rats were subjected to severe SC contusion. Specimens were analyzed from day 1 to 1 year post-injury. Using conventional light, and transmission and scanning electron microscopy, three stages were typified, namely: necrosis, repair, and stability. The final cell composition and thickness of the cyst walls were not uniform. Astrocytes, fibroblasts, ependymal cells, and collagen fibers were the main constituents. Chronic inflammatory cells were also observed. The neuropathologic characterization of post-traumatic SC cysts could be useful in planning strategies for SC reconstruction at different times post-injury.

AB - To study the development of post-traumatic spinal cord (SC) cysts, and their fine anatomic characteristics, rats were subjected to severe SC contusion. Specimens were analyzed from day 1 to 1 year post-injury. Using conventional light, and transmission and scanning electron microscopy, three stages were typified, namely: necrosis, repair, and stability. The final cell composition and thickness of the cyst walls were not uniform. Astrocytes, fibroblasts, ependymal cells, and collagen fibers were the main constituents. Chronic inflammatory cells were also observed. The neuropathologic characterization of post-traumatic SC cysts could be useful in planning strategies for SC reconstruction at different times post-injury.

KW - Experimental spinal cord injury

KW - Paraplegia

KW - Post-traumatic cysts

KW - Spinal cord contusion

UR - https://www.scopus.com/pages/publications/0028228366

U2 - 10.1016/0090-3019(94)90131-7

DO - 10.1016/0090-3019(94)90131-7

M3 - Artículo

C2 - 8146742

AN - SCOPUS:0028228366

SN - 0090-3019

VL - 41

SP - 241

EP - 249

JO - Surgical Neurology

JF - Surgical Neurology

IS - 3

ER -

Development of post-traumatic cysts in the spinal cord of rats subjected to severe spinal cord contusion

Abstract

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