Enhancing the Affinity of a Novel Selective scFv for Soluble ST2 through Computational Design

Biochemistry, Genetics and Molecular Biology

• Interleukin 33 100%
• Isoform 66%
• Tissue Repair 66%
• Interleukin-1 33%
• Binding Affinity 33%
• Peptide Sequence 33%
• Cross Reaction 33%
• Flow Cytometry 33%
• Phage Display 33%
• Immunoprecipitation 33%
• Immunoregulation 33%
• Single-Chain Variable Fragment 33%
• C-Terminus 33%
• Conformation 33%
• Surface Plasmon Resonance 33%
• Binding Residue 33%

Immunology and Microbiology

• Interleukin 33 100%
• Tissue Repair 66%
• Cross-Reactivity 33%
• Immunoregulation 33%
• Ulcerative Colitis 33%
• Interleukin 1 33%
• Inflammatory Disorder 33%
• Amino Acid Sequence 33%
• Phage Display 33%
• Binding Affinity 33%
• Immunoprecipitation 33%
• Single-Chain Variable Fragment 33%
• Surface Plasmon Resonance 33%
• Conformation 33%
• Asthma 33%
• Carboxy Terminal Sequence 33%
• Cardiovascular System 33%

Keyphrases

• Soluble Suppression of Tumorigenicity 2 (sST2) 100%
• Computational Design 100%
• ScFv 100%
• ST2L 36%
• Interleukin-33 (IL-33) 27%
• Tissue Repair 18%
• Disease Severity 9%
• Ulcerative Colitis 9%
• Immune Regulation 9%
• Cardiovascular Disease 9%
• Flow Cytometry 9%
• High Specificity 9%
• High Selectivity 9%
• Amino Acid Sequence 9%
• Cross-reactivity 9%
• Inflammatory Diseases 9%
• Phage Display Library 9%
• Fold Increase 9%
• Asthma 9%
• Transmembrane 9%
• Binding Affinity 9%
• Signaling Axis 9%
• Key Binding 9%
• Decoy Receptor 9%
• Molecular Simulation 9%
• Diagnostic Use 9%
• Surface Plasmon Resonance Analysis 9%
• Clinical Evidence 9%
• Co-immunoprecipitation (co-IP) 9%
• IL-1 Receptor 9%
• Enhanced Specificity 9%
• Binding Residues 9%
• Single-chain Variable Fragment 9%
• C-terminus 9%
• Therapeutic Applications 9%
• Membrane-bound 9%