TY - JOUR
T1 - Short report
T2 - Neonatal screening pilot study of Toxoplasma gondii congenital infection in Mexico
AU - Vela-Amieva, Marcela
AU - Cañedo-Solares, Irma
AU - Gutiérrez-Castrellón, Pedro
AU - Pérez-Andrade, Martha
AU - González-Contreras, Claudia
AU - Ortíz-Cortés, Joel
AU - Ortega-Velázquez, Venancio
AU - Galván-Ramírez, Maria De La Luz
AU - Ruiz-García, Matilde
AU - Saltigeral-Simentel, Patrica
AU - Ordaz-Favila, Juan Carlos
AU - Sánchez, Carmen
AU - Correa, Dolores
PY - 2005/1/1
Y1 - 2005/1/1
N2 - Congenital toxoplasmosis is an obstetric problem in Mexico, but its actual frequency is unknown. Using a network for screening of non-infectious disorders, we performed a pilot study to determine the frequency of IgM antibodies to Toxoplasma gondii in 1,003 infants (53.1% male, mean ± SD age = 18.3 ± 13.0 days, birth weight = 3.116 ± 0.453 kg) in Mexico City from March to April 2003. Blood samples embedded in filter paper were assayed for IgM antibodies using a capture enzyme-linked immunosorbent assay and results were confirmed by Western blot. Two asymptomatic newborns, one of them premature, had IgM and IgG antibodies in a serum sample taken from both the infant and the mother and were clinically followed. Our data suggest a frequency of approximately two cases of congenital T. gondii infection per 1,000 newborns in Mexico City.
AB - Congenital toxoplasmosis is an obstetric problem in Mexico, but its actual frequency is unknown. Using a network for screening of non-infectious disorders, we performed a pilot study to determine the frequency of IgM antibodies to Toxoplasma gondii in 1,003 infants (53.1% male, mean ± SD age = 18.3 ± 13.0 days, birth weight = 3.116 ± 0.453 kg) in Mexico City from March to April 2003. Blood samples embedded in filter paper were assayed for IgM antibodies using a capture enzyme-linked immunosorbent assay and results were confirmed by Western blot. Two asymptomatic newborns, one of them premature, had IgM and IgG antibodies in a serum sample taken from both the infant and the mother and were clinically followed. Our data suggest a frequency of approximately two cases of congenital T. gondii infection per 1,000 newborns in Mexico City.
UR - https://www.scopus.com/pages/publications/15844385662
U2 - 10.4269/ajtmh.2005.72.142
DO - 10.4269/ajtmh.2005.72.142
M3 - Artículo
C2 - 15741549
AN - SCOPUS:15844385662
SN - 0002-9637
VL - 72
SP - 142
EP - 144
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 2
ER -