Cyclosporin-A inhibits inducible nitric oxide synthase activity and expression after spinal cord injury in rats
- Araceli Diaz-Ruiz,
- Paula Vergara,
- Francisca Perez-Severiano,
- Jose Segovia,
- Gabriel Guizar-Sahagún,
- Instituto Nacional de Neurologia y Neurocirugia,
- Centro de Investigacion y de Estudios Avanzados del Instituto Politécnico Nacional,
- Instituto Mexicano del Seguro Social,
- Hospital de Especialidades
Research Output: Contribution to journal Article Peer-review
Publication Information
Output type
Research Output: Contribution to journal Article Peer-review
Original language
EnglishPages from-to (Number of pages)
Pages 49-52 (4 pages)Journal (Volume, Issue Number)
Neuroscience Letters (Volume 357, Issue 1)Publication milestones
- Published - 26/02/2004
Publication status
Published - 26/02/2004
ISSN
0304-3940Publication IDs
- Scopus: 0442276442
- PubMed: 15036611
Abstract
Nitric oxide is generated from L-arginine by a family of three distinct nitric oxide synthase (NOS) enzymes playing a crucial role in the physiopathology of spinal cord injury (SCI). Cyclosporin-A (CsA), an immunosupressive agent, may be used to inhibit the activity of iNOS and perhaps to protect against neural tissue destruction. Rats were submitted to SCI by contusion, and killed 4, 24 and 72 h after lesion. Results showed an increase in the activity of iNOS at 72 h after the SCI, inhibited by CsA (2.5 mg/kg) administered 12 h after trauma. iNOS Western blot assay showed an increase in the expression of iNOS after trauma, also antagonized by CsA administration.
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