Cyclosporin-A inhibits lipid peroxidation after spinal cord injury in rats
- Araceli Diaz-Ruizb, c(Author),
- Camilo Riosc(Author),
- Ivonne Duarteb(Author),
- ,
- Gabriel Guizar-Sahagunb(Author),
- Israel Grijalvab(Author)
- aSSA Mexico,
- bInstituto Mexicano del Seguro Social,
- cInstituto Nacional de Neurologia y Neurocirugia
Publication Information
Output type
Original language
EnglishPages from-to (Number of pages)
Pages 61-64 (4 pages)Journal (Volume, Issue Number)
Neuroscience Letters (Volume 266, Issue 1)Publication milestones
- Published - 30/04/1999
Publication status
ISSN
0304-3940External Publication IDs
- Scopus: 0345711646
- PubMed: 10336184
Abstract
Besides its immunosuppressive/anti-inflammatory activity, cyclosporin-A (CsA) may protect damaged tissues from lipid peroxidation (LP) by free radicals. To determine the effect of CsA on LP spinal cord (SC) injury, Wistar rats were treated with either vehicle or CsA (2.5 mg/kg per 12 h i.p.) 1, 2, 6 or 12 h after SC trauma by T8-T9 spinal cord contusion, analyzing LP 24 h after injury at the lesion site by the lipid fluorescent products formation method. CsA significantly diminished LP to levels below control values after contusion (P < 0.05). The greater inhibition was observed when CsA was given during the first 6 h after injury, furthermore, animals showed a significant clinical improvement. Results show that CsA may be beneficial to injured tissue by inhibiting the levels of LP.