Detrimental role of prolonged sleep deprivation on adult neurogenesis
- Carina Fernandese(Author),
- Nuno Barbosa F. Rochah(Author),
- Susana Rochah(Author),
- Andrea Herrera-Solísb(Author),
- José Salas-Pachecoc(Author),
- Fabio García-Garcíaf(Author)
- ,
- bUniversidad Nacional Autónoma de México,
- cUniversidad Juarez del Estado de Durango,
- dUniversidade Salgado de Oliveira,
- eUniversity of Porto,
- fUniversidad Veracruzana
Open access
Publication Information
Output type
Original language
EnglishArticle number
A140Journal (Volume, Issue Number)
Frontiers in Cellular Neuroscience (Volume 9, Issue APR)Publication milestones
- Published - 14/04/2015
Publication status
ISSN
1662-5102External Publication IDs
- Scopus: 84927610564
Abstract
Adult mammalian brains continuously generate new neurons, a phenomenon called adult neurogenesis. Both environmental stimuli and endogenous factors are important regulators of adult neurogenesis. Sleep has an important role in normal brain physiology and its disturbance causes very stressful conditions, which disrupt normal brain physiology. Recently, an influence of sleep in adult neurogenesis has been established, mainly based on sleep deprivation studies. This review provides an overview on how rhythms and sleep cycles regulate hippocampal and subventricular zone neurogenesis, discussing some potential underlying mechanisms. In addition, our review highlights some interacting points between sleep and adult neurogenesis in brain function, such as learning, memory, and mood states, and provides some insights on the effects of antidepressants and hypnotic drugs on adult neurogenesis.