Development and characterization of nanocapsules comprising dodecyltrimethylammonium chloride and κ-carrageenan
- A. Rosas-Durazo,
- J. Lizardi,
- ,
- W. Argüelles-Monal,
- F. M. Goycoolea(corresponding author)
- Centro de Investigacion en Alimentacion y Desarrollo,
- Centro de Investigacion Cientifica de Yucatan,
- University of Santiago de Compostela,
- Departamento de Farmacia
Open access
Publication Information
Output type
Original language
EnglishPages from-to (Number of pages)
Pages 242-246 (5 pages)Journal (Volume, Issue Number)
Colloids and Surfaces B: Biointerfaces (Volume 86, Issue 1)Publication milestones
- Published - 01/08/2011
Publication status
ISSN
0927-7765Publication IDs
- Scopus: 79955854641
- PubMed: 21497069
Abstract
The aim of this work was to develop and characterize a new type of nanocapsules. To this end, a nanoemulsion bearing an oily core (Miglyol 812) was obtained by spontaneous emulsification and stabilized by dodecyl-trimethylammonium chloride (DTAC), a commercial cationic surfactant; this nanoemulsion was coated with proportionally very small amounts of κ-carrageenan (at molar charge ratios of Z≤ 0.0045) that interact predominantly by an electrostatic mechanism with the positively charged sites at the polar heads of DTAC at the nanoemulsion's surface to harness nanocapsules of average size ∼250-330. nm and zeta potential (ζ) ranging from ∼+80 to +7. mV. The potential application of the new type of developed nanosystems as drug delivery vehicles has yet to be investigated and fully realized.