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Development of post-traumatic cysts in the spinal cord of rats subjected to severe spinal cord contusion

  • Gabriel Guizar-Sahaguna, b, c(Author)
    ,
  • Israel Grijalvaa, b, c(Author)
    ,
  • Ignacio Madrazoa, b, c(Author)
    ,
  • Rebecca Franco-Bourlanda, b, c(Author)
    ,
  • Hermelinda Salgadoa, b, c(Author)
    ,
  • Antonio Ibarraa, b, c(Author)
  • aUniversidad Nacional Autónoma de México
    ,
  • bInstituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
    ,
  • cHospital de Especialidades
Research Output: Contribution to journal Article Peer-review

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 241-249 (9 pages)

Journal (Volume, Issue Number)

Surgical Neurology (Volume 41, Issue 3)

Publication milestones

  • Published - 01/01/1994

Publication status

Published - 01/01/1994

ISSN

0090-3019

External Publication IDs

  • Scopus: 0028228366
  • PubMed: 8146742

Abstract

To study the development of post-traumatic spinal cord (SC) cysts, and their fine anatomic characteristics, rats were subjected to severe SC contusion. Specimens were analyzed from day 1 to 1 year post-injury. Using conventional light, and transmission and scanning electron microscopy, three stages were typified, namely: necrosis, repair, and stability. The final cell composition and thickness of the cyst walls were not uniform. Astrocytes, fibroblasts, ependymal cells, and collagen fibers were the main constituents. Chronic inflammatory cells were also observed. The neuropathologic characterization of post-traumatic SC cysts could be useful in planning strategies for SC reconstruction at different times post-injury.

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