Skip to search boxSkip to navigationSkip to main content

Early effects of modulating nuclear factor-κB activation on traumatic spinal cord injury in rats

  • Octavio Jiménez-Garzab(Author)
    ,
  • Javier Camachob(Author)
    ,
  • Antonio Ibarraa(Author)
    ,
  • Angelina Martíneza(Author)
    ,
  • Gabriel Guízar-Sahagúna(Author)
  • aInstituto Mexicano del Seguro Social
    ,
  • bCentro de Investigacion y de Estudios Avanzados del Instituto Politécnico Nacional
Research Output: Contribution to journal Article Peer-review

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 148-150 (3 pages)

Journal (Volume, Issue Number)

Annals of the New York Academy of Sciences (Volume 1053)

Publication milestones

  • Published - 01/01/2005

Publication status

Published - 01/01/2005

ISSN

0077-8923

External Publication IDs

  • Scopus: 29744458521
  • PubMed: 16179517

Abstract

Genes regulated by NF-κB play an important role on secondary damage and repair after spinal cord injury (SCI). To assess the early effects of the pharmacological inhibition and overactivation of NF-κB, pyrrolidine dithiocarbamate (PDTC) or lipopolysaccharide were given to rats before or after SC contusion. The amount of spared SC tissue was higher (P < 0.05) at 24 h postinjury in rats posttreated with PDTC; both PDTC-treated rats showed no significant trend to decrease polymorphonuclear infiltrate. p65 subunit was present in inflammatory cells, neurons, and astrocytes at the injury site. These data support further investigation on functional effects of NF-κB inhibition in acute SCI.

Access to documents

Publication metrics

Metrics

SciVal
FWCI
0.28