Identification of CD4+ T cell epitopes of Taenia solium paramyosin
- H. S. López-Morenoc(Author),
- ,
- J. P. Laclettea(Author),
- V. F. Ortiz-Navarretec(Author)
- aUniversidad Nacional Autónoma de México,
- bInstituto Nacional de Pediatria,
- cCentro de Investigacion y de Estudios Avanzados del Instituto Politécnico Nacional
Publication Information
Output type
Original language
EnglishPages from-to (Number of pages)
Pages 513-516 (4 pages)Journal (Volume, Issue Number)
Parasite Immunology (Volume 25, Issue 10)Publication milestones
- Published - 01/10/2003
Publication status
ISSN
0141-9838External Publication IDs
- Scopus: 1542407035
- PubMed: 15157028
Abstract
T cell mediated response is involved in a protective immune response against experimental cysticercosis conferred by immunization with Taenia solium paramyosin (TPmy) to BALB/c mice. In this study, we analysed the TPmy amino acid sequence for predicted CD4+ T cells epitopes. Five different regions of this protein showed that the residues anchor to bind the I-A d molecule; synthetic peptides containing these epitopes were evaluated for their ability to induce lymphoproliferative responses of spleen cells from TPmy immunized mice. Among them, Tp176 (amino acids 176-192 sequence DDLQRQMADANSAKSRL) was the immunodominant T cell epitope of TPmy. Delineation of this epitope should facilitate analysis of the role of CD4+ T cell response in experimental cysticercosis.