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Promoting of wakefulness by administrations of modafinil into anterior hypothalamus and into the pedunculopontine tegmental nucleus in rats

  • Universidad Autónoma de Campeche
    ,
  • Universidad Nacional Autónoma de México
    ,
  • Facultad de Medicina
Research Output: Contribution to journal Article Peer-review

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 283-287 (5 pages)

Journal (Volume, Issue Number)

Neuroscience Letters (Volume 436, Issue 2)

Publication milestones

  • Published - 09/05/2008

Publication status

Published - 09/05/2008

ISSN

0304-3940

Publication IDs

  • Scopus: 41949084977
  • PubMed: 18403119

Abstract

We investigated whether administration of MOD in rats during the lights-on period into wake-promoting areas, such as anterior hypothalamus (AH) or into the pedunculopontine tegmental nucleus (PPTg) would enhance waking. Results showed that microinjections of 1 μL of MOD (10, 20, or 30 μg) into both brain areas increased the total time of alertness and decreased sleep. Additionally, MOD-treated rats showed an enhancement in alpha power spectra but delta power spectra was diminished. Finally, c-Fos expression was found increased into either AH or the PPTg. Collectively, these results suggest that MOD induces waking via the activity of two wake-related brain areas such as AH and the PPTg.

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