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Search for an IgG response against neural antigens in experimental spinal cord injury

  • A. Ibarraa, b, c(Author)
    ,
  • S. Martinezb(Author)
    ,
  • J. Reyesb(Author)
    ,
  • A. Meza-Lucasa(Author)
    ,
  • A. Mandujanoa(Author)
    ,
  • I. Grijalvab, c(Author)
  • aSSA Mexico
    ,
  • bInstituto Mexicano del Seguro Social
    ,
  • cUnidad de Inv. Med. en Enf. Neurol.
Research Output: Contribution to journal Article Peer-review

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 3-5 (3 pages)

Journal (Volume, Issue Number)

Neuroscience (Volume 96, Issue 1)

Publication milestones

  • Published - 01/01/2000

Publication status

Published - 01/01/2000

ISSN

0306-4522

External Publication IDs

  • Scopus: 0033964952
  • PubMed: 10683404

Abstract

In order to determine if a specific response is induced after spinal cord injury, we performed a kinetic search for IgG antibodies against various spinal cord antigenic preparations in a rat contusion model. Even though spinal cord injured animals showed two reactive bands, these could be originated by the reaction of natural antibodies, since they were also observed before lesion. Thus, these antibodies would not be of relevance in the pathogenic events of spinal cord injury in this rat model. Our findings do not demonstrate the existence of a specific IgG response against spinal cord constituents after injury. Copyright (C) 1999 IBRO.

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