Sleep and neurochemical modulation by the nuclear peroxisome proliferator-activated receptor α (PPAR-α) in rat
- Stephanie Mijangos-Moreno,
- Alwin Poot-Aké,
- Khalil Guzmán,
- Gloria Arankowsky-Sandoval,
- Oscar Arias-Carrión,
- Jaime Zaldívar-Rae
- Universidad Anáhuac,
- Universidad Nacional Autónoma de México,
- Universidad Autonoma de Yucatan,
- Hospital General "Dr. Manuel Gea González",
Publication Information
Output type
Original language
EnglishPages from-to (Number of pages)
Pages 65-69 (5 pages)Journal (Volume, Issue Number)
Neuroscience Research (Volume 105)Publication milestones
- Published - 01/04/2016
Publication status
ISSN
0168-0102Publication IDs
- Scopus: 84973100062
- PubMed: 26450400
Abstract
The peroxisome proliferator-activated receptor alpha (PPARα) is a nuclear protein that plays an essential role in diverse neurobiological processes. However, the role of PPARα on the sleep modulation is unknown. Here, rats treated with an intrahypothalamic injection of Wy14643 (10 μg/1 μL; PPARα agonist) enhanced wakefulness and decreased slow wave sleep and rapid eye movement sleep whereas MK-886 (10 μg/1 μL; PPARα antagonist) promoted opposite effects. Moreover, Wy14643 increased dopamine, norepinephrine, serotonin, and adenosine contents collected from nucleus accumbens. The levels of these neurochemicals were diminished after MK-886 treatment. The current findings suggest that PPARα may participate in the sleep and neurochemical modulation.