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Lipid peroxidation inhibition in spinal cord injury: Cyclosporin-A vs methylprednisolone

  • Aracell Diaz-Ruiz
    ,
  • Camilo Rios
    ,
  • Ivonne Duarte
    ,
  • Dolores Correa
    ,
  • Gabriel Guizar-Sahagun
    ,
  • Israel Grijalva
*Corresponding author for this work
  • Instituto Mexicano del Seguro Social
    ,
  • Ctro. de Investigacion del P.
    ,
  • Instituto Nacional de Neurologia y Neurocirugia
    ,
  • Secretaría de Salud
Research Output:
Contribution to journal
Article
 Peer review

Publication Information

Tipo di output

Research Output:
Contribution to journal
Article
 Peer review

Lingua originale

English

Pagine da-a (Numero di pagine)

Pagine 1765-1767 (3 pagine)

Rivista (volume, numero edizione)

NeuroReport (Volume 11, Edizione 8)

Attività cardine della pubblicazione

  • Published - 05/06/2000

Stato pubblicazione

Published - 05/06/2000

ISSN

0959-4965

Publication IDs

  • Scopus: 0034608570
  • PubMed: 10852240

Abstract

To compare the effectiveness of cyclosporin-A (CsA) with methylprednisolone (MP) or a combination of both upon inhibition of lipid peroxidation (LP) after spinal cord (SC) injury, rats were treated with either CsA, MP, CSA+MP or vehicle starting 1 h after SC contusion at T9 level. LP was assessed 24h after injury by the lipid fluorescent product formation method. The survival rate was also evaluated in other series of rats by the Kaplan-Meier curves. Lipid peroxidation was similarly inhibited in rats treated with CsA, MP, or CSA+MP (p > 0.05). Animals receiving MP (alone or combined with CsA) showed the poorest surviving rate. LP was inhibited by CsA to the same extent as by MP but without the lethal effect of the latter. (C) 2000 Lippincott Williams and Wilkins.

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