The hypolipidemic effect and antithrombotic activity of Mucuna pruriens protein hydrolysates
- Francisco Herrera Chalé,
- ,
- David Betancur Ancona,
- Juan José Acevedo Fernández,
- Maira Rubi Segura Campos
- Universidad Autonoma de Yucatan,
- Instituto Tecnológico de Mérida,
- Universidad Autonoma del Estado de Morelos
Publication Information
Output type
Original language
EnglishPages from-to (Number of pages)
Pages 434-444 (11 pages)Journal (Volume, Issue Number)
Food and Function (Volume 7, Issue 1)Publication milestones
- Published - 01/01/2016
Publication status
ISSN
2042-6496External Publication IDs
- Scopus: 84956695873
- PubMed: 26505152
Abstract
Hydrolysates and peptide fractions (PF) obtained from M. pruriens protein concentrates with commercial and digestive enzymatic systems were studied for their hypolipidemic and antithrombotic activities. Hydrolysates obtained with Pepsin-Pancreatin (PP) and their peptide fractions inhibited cholesterol micellar solubility with a maximum value of 1.83% in PP. Wistar rats were used to evaluate the hypolipidemic effect of hydrolysates and PF. The higher reductions of cholesterol and triglyceride levels were exhibited by PP and both peptide fractions <1 kDa obtained from PP and Alcalase®-Flavourzyme® hydrolysate (AF) at a dose of 15 mg kg-1 of animal weight. PF > 10 kDa from both hydrolysates showed the maximum antithrombotic activity with values of 33.33% for PF > 10 kDa from AF and 31.72% for PF > 10 kDa from PP. The results suggest that M. pruriens bioactive peptides with the hypolipidemic effect and antithrombotic activity might be utilized as nutraceuticals.